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1.发明授权公开(公告)号：US09255131B2
公开(公告)日：2016-02-09
申请号：US12851980
申请日：2010-08-06
申请人： Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
发明人： Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
IPC分类号： G01N33/53 , G01N33/574 , A61K51/10 , A61K39/395 , C07K14/47 , C12Q1/68
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
摘要翻译： 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。
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公开(公告)号：US20110189179A1
公开(公告)日：2011-08-04
申请号：US13086176
申请日：2011-04-13
申请人： Ugur Sahin , Özlzem Türeci , Michael Koslowski , Dirk Usener
发明人： Ugur Sahin , Özlzem Türeci , Michael Koslowski , Dirk Usener
IPC分类号： A61K39/395 , C07H21/04 , C07K16/30 , C12N5/10 , C12N15/63 , A61K39/00 , C12Q1/68 , A61K35/12 , A61P35/00
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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公开(公告)号：US20090202530A1
公开(公告)日：2009-08-13
申请号：US12066399
申请日：2006-09-06
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Dirk Usener
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Dirk Usener
IPC分类号： A61K39/395 , C12N15/11 , C07K16/18 , C12N5/06 , C12N15/00 , C07K14/00 , C12Q1/68 , C12Q1/02 , G01N33/574 , A61K31/7088 , A61K35/12 , A61K39/00
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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公开(公告)号：US08425902B2
公开(公告)日：2013-04-23
申请号：US12601488
申请日：2008-05-27
申请人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症，胆囊癌及其转移灶。
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5.发明申请公开(公告)号：US20110014628A1
公开(公告)日：2011-01-20
申请号：US12851980
申请日：2010-08-06
申请人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
发明人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
摘要翻译： 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。
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6.发明申请公开(公告)号：US20090214550A1
公开(公告)日：2009-08-27
申请号：US11886758
申请日：2006-03-23
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schlüter
IPC分类号： A61K39/395 , A61K45/00 , C12Q1/68 , G01N33/53 , C12N15/74 , A61K38/16 , A61K31/7088 , C07K16/00 , C07H21/00 , A61P35/00
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
摘要： The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
摘要翻译： 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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7.发明申请公开(公告)号：US20080193454A1
公开(公告)日：2008-08-14
申请号：US11596106
申请日：2005-05-11
申请人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel
发明人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel
IPC分类号： A61K39/395 , C12N15/11 , C12Q1/68 , C12Q1/02 , C12N5/06 , A61K31/70 , A61P43/00 , C07K14/00 , A61K35/12 , G01N33/574 , C07K16/18
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.
摘要翻译： 本发明涉及作为肿瘤相关表达的结果的基因产物的鉴定和编码其的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及作为肿瘤相关表达的结果的蛋白质，多肽和肽以及编码其的核酸。
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公开(公告)号：US08975375B2
公开(公告)日：2015-03-10
申请号：US13086176
申请日：2011-04-13
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Dirk Usener
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Dirk Usener
IPC分类号： C07K16/00 , A61K39/395 , C07K14/47 , C07K16/28 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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公开(公告)号：US20140017254A1
公开(公告)日：2014-01-16
申请号：US13946302
申请日：2013-07-19
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Dirk Usener
IPC分类号： C07K14/47
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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10.发明授权公开(公告)号：US07785801B2
公开(公告)日：2010-08-31
申请号：US11596106
申请日：2005-05-11
申请人： Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
发明人： Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
IPC分类号： G01N33/53
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.
摘要翻译： 本发明涉及作为肿瘤相关表达的结果的基因产物的鉴定和编码其的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及作为肿瘤相关表达的结果的蛋白质，多肽和肽以及编码其的核酸。
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