发明申请
- 专利标题: Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine
- 专利标题(中): AMPA受体的化合物及其用途
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申请号: US12808197申请日: 2008-12-17
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公开(公告)号: US20110021578A1公开(公告)日: 2011-01-27
- 发明人: Nicolas Bertheleme , Wai Ngor Chan , Jaqueline Sandra Scott , Simon E. Ward
- 申请人: Nicolas Bertheleme , Wai Ngor Chan , Jaqueline Sandra Scott , Simon E. Ward
- 申请人地址: GB Greenford Middlesex
- 专利权人: GLAXO GROUP LIMITED
- 当前专利权人: GLAXO GROUP LIMITED
- 当前专利权人地址: GB Greenford Middlesex
- 优先权: GB0724783.6 20071219; GB0818068.9 20081002
- 国际申请: PCT/EP2008/067681 WO 20081217
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; C07C311/13 ; C07D211/70 ; A61K31/18 ; C07D211/72 ; A61P25/18
摘要:
Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, N and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
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