-
1.发明授权公开(公告)号：US08173820B2
公开(公告)日：2012-05-08
申请号：US12808197
申请日：2008-12-17
IPC分类号： C07D211/72 , C07D213/62 , C07C303/00 , A61K31/44 , A61K31/16
CPC分类号： C07C311/08 , C07C2602/08 , C07D213/30 , C07D213/643 , C07D213/65
摘要： Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
摘要翻译： 提供式（I）化合物及其盐：其中n为0,1,2或3; R 1选自苯基和吡啶基，其各自任选被一个或两个独立地选自C 1-4烷基和卤素的基团取代; 当n为1时，R 2选自H和CH 3，当n为2或3时，R 2为H。制备方法，药物组合物及其作为药物的用途，例如用于治疗由 还公开了谷氨酸受体功能的降低或不平衡，例如精神分裂症或认知障碍。
-
公开(公告)号：US20110021578A1
公开(公告)日：2011-01-27
申请号：US12808197
申请日：2008-12-17
IPC分类号： A61K31/44 , C07C311/13 , C07D211/70 , A61K31/18 , C07D211/72 , A61P25/18
CPC分类号： C07C311/08 , C07C2602/08 , C07D213/30 , C07D213/643 , C07D213/65
摘要： Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, N and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
摘要翻译： 提供式（I）化合物及其盐：其中n为0,1,2或3; R 1选自苯基和吡啶基，其各自任选被一个或两个独立地选自C 1-4烷基和卤素的基团取代; 当n为1时，R 2选自H和CH 3，当n为2或3时，R 2为H。制备方法，药物组合物，N及其用作药物，例如用于治疗由 还公开了谷氨酸受体功能的减少或不平衡，例如精神分裂症或认知障碍。
-
公开(公告)号：US20100016330A1
公开(公告)日：2010-01-21
申请号：US12503135
申请日：2009-07-15
申请人： Jag Paul Heer , David Norton , Simon E. Ward
发明人： Jag Paul Heer , David Norton , Simon E. Ward
IPC分类号： A61K31/496 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
-
4.发明授权Tricyclic substituted benzenesulfonamide piperazine derivatives as CAV2.2 calcium channel blockers 有权三环取代苯磺酰胺哌嗪衍生物作为CAV2.2钙通道阻断剂公开(公告)号：US08933132B2
公开(公告)日：2015-01-13
申请号：US13979830
申请日：2012-01-19
申请人： David Norton , Daniele Andreotti , Simon E. Ward , Roberto Profeta , Simone Spada , Helen Susanne Price
发明人： David Norton , Daniele Andreotti , Simon E. Ward , Roberto Profeta , Simone Spada , Helen Susanne Price
IPC分类号： A61K31/10 , C07C317/32 , C07D471/14 , C07D487/14
CPC分类号： C07D471/14 , C07D487/14
摘要： The invention relates to novel piperazine compounds of formula (I): to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial, i.e. in particular to treat pain.
摘要翻译： 本发明涉及式（I）的新型哌嗪化合物：其制备方法; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道的疾病是有益的，即特别是治疗疼痛。
-
公开(公告)号：US20140038976A1
公开(公告)日：2014-02-06
申请号：US13979830
申请日：2012-01-19
申请人： David Norton , Daniele Andreotti , Simon E. Ward , Roberto Profeta , Simone Spada , Helen Susanne Price
发明人： David Norton , Daniele Andreotti , Simon E. Ward , Roberto Profeta , Simone Spada , Helen Susanne Price
IPC分类号： C07D471/14
CPC分类号： C07D471/14 , C07D487/14
摘要： The invention relates to novel piperazine compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial, i.e. in particular to treat pain.
摘要翻译： 本发明涉及新型哌嗪化合物; 进行准备; 包含该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道的疾病是有益的，即特别是治疗疼痛。
-
公开(公告)号：US09115132B2
公开(公告)日：2015-08-25
申请号：US13808243
申请日：2011-07-08
申请人： Paul Beswick , Robert James Gleave , Shuji Hachisu , Sadie Vile , Nicholas Bertheleme , Simon E. Ward
发明人： Paul Beswick , Robert James Gleave , Shuji Hachisu , Sadie Vile , Nicholas Bertheleme , Simon E. Ward
IPC分类号： A61K31/41 , C07D401/14 , C07D403/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/08 , C07D513/04 , C07D257/04 , C07D257/06
CPC分类号： A61K31/41 , A61K31/435 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/551 , C07D257/04 , C07D257/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/08 , C07D513/04
摘要： The present invention relates to novel tetrazole compounds of Formula (I) wherein A is (II) or (III); to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial. wherein A is
摘要翻译： 本发明涉及式（I）的新型四唑化合物，其中A为（II）或（III）; 进行准备; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道有益的疾病。 其中A是
-
公开(公告)号：US20130210796A1
公开(公告)日：2013-08-15
申请号：US13808243
申请日：2011-07-08
申请人： Paul Beswick , Robert James Gleave , Shuji Hachisu , Sadie Vile , Nicholas Bertheleme , Simon E. Ward
发明人： Paul Beswick , Robert James Gleave , Shuji Hachisu , Sadie Vile , Nicholas Bertheleme , Simon E. Ward
IPC分类号： C07D471/10 , C07D413/06 , C07D417/06 , C07D403/06
CPC分类号： A61K31/41 , A61K31/435 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/551 , C07D257/04 , C07D257/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/08 , C07D513/04
摘要： The present invention relates to novel tetrazole compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial. Formula (I) wherein A is: (II) or (III) wherein A is
摘要翻译： 本发明涉及新型四唑化合物; 进行准备; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道有益的疾病。 式（I）其中A为：（II）或（III）其中A为
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.027 秒)
