发明申请
US20110028482A1 ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE
有权
作为脂肪酸酰胺水解酶抑制剂的ISOXAZOLINES
- 专利标题： ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE
- 专利标题（中）： 作为脂肪酸酰胺水解酶抑制剂的ISOXAZOLINES
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申请号： US12782655申请日： 2010-05-18
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公开(公告)号： US20110028482A1公开(公告)日： 2011-02-03
- 发明人: Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
- 申请人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
- 申请人地址： US MA Cambridge
- 专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K31/498
- IPC分类号： A61K31/498 ; C07D413/04 ; A61K31/42 ; C07D417/14 ; A61K31/4439 ; C07D401/14 ; A61K31/506 ; A61K31/427 ; C07D401/04 ; A61K31/454 ; C07D413/06 ; A61K31/496 ; C07D417/10 ; A61K31/428 ; C07D403/10 ; C07D401/10 ; A61K31/4709 ; A61P1/00 ; A61P3/00 ; A61P9/00 ; A61P17/00 ; A61P25/00 ; A61P27/06 ; A61P29/00
摘要：
The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
公开/授权文献
- US08927551B2 Isoxazolines as inhibitors of fatty acid amide hydrolase 公开/授权日：2015-01-06
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