Inhibitors of fatty acid amide hydrolase
    1.
    发明授权
    Inhibitors of fatty acid amide hydrolase 有权
    脂肪酸酰胺水解酶抑制剂

    公开(公告)号:US08957049B2

    公开(公告)日:2015-02-17

    申请号:US12901421

    申请日:2010-10-08

    IPC分类号: C07F5/02 A61K31/69

    CPC分类号: C07F5/025 A61K31/69 C07F5/02

    摘要: The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof.

    摘要翻译: 本发明提供了由式(I),(II),(III),(IV),(V)或(VI)或其子类中的任何一种包含的化合物及其药学上可接受的组合物。 本发明还提供了通过施用治疗有效量的化合物或组合物来治疗FAAH介导的疾病,病症或病症的方法,所述化合物或组合物包含式(I),(II),(III),(IV), (Ⅴ)或(Ⅵ)或其子代的药物给予有需要的患者。 另外,本发明提供了通过施用治疗有效量的包含式(I),(II),(III),(IV),(V)或((IV))的化合物的化合物或组合物来抑制FAAH的方法, VI)或其子集合。

    TURBINE BLADE DAMPER SEAL
    5.
    发明申请
    TURBINE BLADE DAMPER SEAL 审中-公开
    涡轮叶片阻尼器密封

    公开(公告)号:US20130195665A1

    公开(公告)日:2013-08-01

    申请号:US13362552

    申请日:2012-01-31

    IPC分类号: F01D11/00 F01D5/14

    摘要: A damper seal received in a cavity of a turbine blade located between a platform and a retention shelf damper seal according to an exemplary aspect of the present disclosure includes, among other things, a central body portion having a first end region, an opposing second end region, and a width. The damper seal further includes a first portion extending from the first end region of the central body portion, and a first end region of the first portion includes first outwardly extending tabs that define a first enlarged portion that has a first width greater than the width of the central body portion and a second portion extending from the opposing second end region of the central body portion.

    摘要翻译: 根据本公开的示例性方面,容纳在位于平台和保持架阻尼器密封件之间的涡轮机叶片的空腔中的阻尼器密封件包括中心主体部分,其具有第一端部区域,相对的第二端部 区域和宽度。 阻尼器密封件还包括从中心主体部分的第一端部区域延伸的第一部分,并且第一部分的第一端部区域包括第一向外延伸的突片,其限定第一扩大部分,第一扩大部分具有大于 中心主体部分和从中心主体部分的相对的第二端部区域延伸的第二部分。

    Contoured Metallic Casting Core
    10.
    发明申请
    Contoured Metallic Casting Core 审中-公开
    轮廓金属铸造芯

    公开(公告)号:US20110315336A1

    公开(公告)日:2011-12-29

    申请号:US12823165

    申请日:2010-06-25

    IPC分类号: B22D25/00 B22C9/10 B22C9/02

    CPC分类号: B22C9/10 B22C9/103 B22C9/24

    摘要: A method for manufacturing an investment casting core uses a metallic blank having a thickness between parallel first and second faces less than a width and length transverse thereto. The blank is locally thinned from at least one of the first and second faces. The local thinning forms a taper on a leading portion of the RMC. The blank is through-cut across the thickness. The blank is inserted into the leading portion into a slot in a pre-formed ceramic core.

    摘要翻译: 用于制造熔模铸造芯的方法使用在平行的第一和第二表面之间的厚度小于横向于其的宽度和长度的金属坯料。 坯料从第一和第二面中的至少一个局部变薄。 局部变薄在RMC的引导部分形成锥形。 空白是穿过厚度的横切。 将坯料插入到预成形的陶瓷芯中的引导部分中的槽中。