Invention Application
- Patent Title: Catheter injectable depot compositions and uses thereof
- Patent Title (中): 导管可注射药剂组合物及其用途
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Application No.: US12925408Application Date: 2010-10-18
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Publication No.: US20110046606A1Publication Date: 2011-02-24
- Inventor: Guohua Chen , Paul R. Houston , Lothar Kleiner , John J. Spaltro
- Applicant: Guohua Chen , Paul R. Houston , Lothar Kleiner , John J. Spaltro
- Assignee: Durect Corporation
- Current Assignee: Durect Corporation
- Main IPC: A61M25/00
- IPC: A61M25/00 ; A61K47/10 ; A61K47/14 ; A61K47/38 ; A61K47/36 ; A61K47/32 ; A61K47/04 ; A61K47/34 ; A61K38/43 ; A61K38/02 ; A61K38/22 ; A61K31/715 ; A61K31/7088 ; A61K31/56 ; A61K39/395 ; A61K38/27 ; A61K38/18 ; A61K38/30 ; A61K38/20 ; A61K38/21 ; A61K38/19 ; A61K9/14 ; A61P37/06 ; A61P23/02 ; A61P29/00 ; A61P31/00 ; A61P35/00 ; A61P7/02 ; A61P27/02

Abstract:
Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
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