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    Fabricating an implantable medical device from an amorphous or very low crystallinity polymer construct
    2.
    发明授权
    Fabricating an implantable medical device from an amorphous or very low crystallinity polymer construct 有权
    从无定形或非常低的结晶度聚合物构造制造可植入医疗器械

    公开(公告)号：US08372332B2

    公开(公告)日：2013-02-12

    申请号：US12465570

    申请日：2009-05-13

    Applicant: Yunbing Wang ,  Lothar Kleiner

    Inventor： Yunbing Wang ,  Lothar Kleiner

    IPC: B29C49/04 ,  B29C49/64 ,  B29C49/08

    CPC classification number: B29D23/00 ,  A61L31/06 ,  A61L31/14 ,  B29C71/0063 ,  C08L67/04

    Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing, nucleating agents, or both are disclosed herein. A polymeric construct that is completely amorphous or that has a very low crystallinity is annealed with no or substantially no crystal growth to increase nucleation density. Alternatively, the polymer construct includes nucleating agent. The crystallinity of the polymer construct is increased with a high nucleation density through an increase in temperature, deformation, or both. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the increase in crystallinity.

    Abstract translation: 本文公开了通过退火，成核剂或两者制造具有改善的断裂韧性的聚合物可植入装置的方法。 完全无定形或具有非常低的结晶度的聚合物构件被退火，没有或基本上没有晶体生长以增加成核密度。 或者，聚合物构造物包括成核剂。 通过增加温度，变形或两者，聚合物构造物的结晶度随着成核密度的增加而增加。 在结晶度增加之后，可以由聚合物构造体制造可植入的医疗装置，例如支架。

    Catheter injectable depot compositions and uses thereof
    3.
    发明授权
    Catheter injectable depot compositions and uses thereof 失效
    导管可注射药剂组合物及其用途

    公开(公告)号：US07829109B2

    公开(公告)日：2010-11-09

    申请号：US10295603

    申请日：2002-11-14

    Applicant: Guohua Chen ,  Paul R. Houston ,  Lothar Kleiner ,  John Spaltro

    Inventor： Guohua Chen ,  Paul R. Houston ,  Lothar Kleiner ,  John Spaltro

    IPC: A61F2/02

    CPC classification number: A61K9/0024 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

    Abstract: Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

    Abstract translation: 提供导管可注射贮库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中具有小于或等于7重量％的混溶性的溶剂。 ％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。 溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。 组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

    Blends of poly(ester amide) polymers
    6.
    发明申请
    Blends of poly(ester amide) polymers 有权
    聚（酯酰胺）聚合物的共混物

    公开(公告)号：US20060074191A1

    公开(公告)日：2006-04-06

    申请号：US10960381

    申请日：2004-10-06

    Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Lothar Kleiner

    Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Lothar Kleiner

    IPC: C08L77/00 ,  C08G69/48

    CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

    Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    Injectable multimodal polymer depot compositions and uses thereof
    9.
    发明授权
    Injectable multimodal polymer depot compositions and uses thereof 失效
    可注射多峰聚合物储库组合物及其用途

    公开(公告)号：US08501215B2

    公开(公告)日：2013-08-06

    申请号：US10628984

    申请日：2003-07-28

    Applicant: Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Jeremy Wright

    Inventor： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Jeremy Wright

    IPC: A61F2/00 ,  A61F13/00 ,  A61K9/14

    CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/2013 ,  A61K47/12 ,  A61K47/14

    Abstract: Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified average molecular weight, and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

    Abstract translation: 提供了可注射的储库组合物，其包括具有多个生物可腐蚀的生物相容性聚合物的聚合物基质，其中所述多种聚合物中的每种聚合物具有指定的平均分子量，并且所述聚合物基质具有所述多种聚合物的宽分子量分布; 在25℃下在水中具有小于或等于7重量％的混溶性的溶剂，其量有效塑化聚合物并与其形成凝胶; 和有益的代理人。 组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

    Stent coating method
    10.
    发明授权
    Stent coating method 有权
    支架涂布法

    公开(公告)号：US08318236B2

    公开(公告)日：2012-11-27

    申请号：US13162937

    申请日：2011-06-17

    Applicant: Jason Van Sciver ,  Yung-Ming Chen ,  Lothar Kleiner

    Inventor： Jason Van Sciver ,  Yung-Ming Chen ,  Lothar Kleiner

    IPC: B05D1/02 ,  A61F2/06 ,  B41J2/04 ,  B41J2/06

    CPC classification number: B05D1/002

    Abstract: A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir.

    Abstract translation: 通过从包含涂层物质的储存器喷射涂层物质的液滴来涂覆支架。 储存器壳体可以具有多个储存室。 传感器用于从储存器中喷射涂层物质。 传感器的能量集中在弯液面或涂层物质与储层中另一种涂料之间的界面。

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