发明申请
US20110053943A1 CARBAMATE AND UREA INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE 1
有权
11β-羟基脱氢酶脱氢酶的碳酸盐和尿素抑制剂1
- 专利标题： CARBAMATE AND UREA INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE 1
- 专利标题（中）： 11β-羟基脱氢酶脱氢酶的碳酸盐和尿素抑制剂1
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申请号： US12791592申请日： 2010-06-01
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公开(公告)号： US20110053943A1公开(公告)日： 2011-03-03
- 发明人: David A. Claremon , Colin M. Tice , Linghang Zhuang , Katerina Leftheris , Yuanjie Ye , Suresh B. Singh
- 申请人： David A. Claremon , Colin M. Tice , Linghang Zhuang , Katerina Leftheris , Yuanjie Ye , Suresh B. Singh
- 专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人： Vitae Pharmaceuticals, Inc.
- 主分类号： A61K31/5025
- IPC分类号： A61K31/5025 ; C07D401/12 ; A61K31/4439 ; C07D487/04 ; C07D207/06 ; A61K31/40 ; C07D211/64 ; A61K31/451 ; C07D211/62 ; A61K31/445 ; C07D211/22 ; C07D401/10 ; A61K31/4709 ; C07D413/04 ; A61K31/4245 ; C07D403/04 ; A61K31/506 ; A61P27/06 ; A61P3/04 ; A61P3/10 ; A61P9/12 ; A61P3/06 ; A61P25/00 ; A61P19/00 ; A61P17/02
摘要：
This invention relates to novel compounds of the invention pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.