发明申请
- 专利标题： HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY
- 专利标题（中）： 人类抗人ALPHA 9整合抗体
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申请号： US12812341申请日： 2009-01-09
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公开(公告)号： US20110059077A1公开(公告)日： 2011-03-10
- 发明人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
- 申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
- 申请人地址： JP KUMAMOTO-SHI JP TOKYO
- 专利权人： JURIDICAL FDN THE CHEMO-SERO-THERAPEUTIC RES INST.,ASTELLAS PHARMA INC.
- 当前专利权人： JURIDICAL FDN THE CHEMO-SERO-THERAPEUTIC RES INST.,ASTELLAS PHARMA INC.
- 当前专利权人地址： JP KUMAMOTO-SHI JP TOKYO
- 优先权： JP2008-004975 20080111; JP2008-282496 20081031
- 国际申请： PCT/JP2009/050187 WO 20090109
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C12N15/13 ; C12N15/70 ; C12N1/21 ; C12P21/08 ; A61K39/395
摘要：
The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
公开/授权文献
- US08603476B2 Humanized anti-human α9-integrin antibody 公开/授权日：2013-12-10
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