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公开(公告)号：US08603476B2
公开(公告)日：2013-12-10
申请号：US12812341
申请日：2009-01-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号： A61K39/395
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。
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公开(公告)号：US20110059077A1
公开(公告)日：2011-03-10
申请号：US12812341
申请日：2009-01-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含由SEQ ID NO：17所示的重链可变区组成的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中，其使用抗体。
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公开(公告)号：US20110014193A1
公开(公告)日：2011-01-20
申请号：US12812368
申请日：2009-07-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.
摘要翻译： 本发明提供了与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即人源化抗人α9整联蛋白抗体，其包含由以下组成的重链可变区： SEQ ID NO：1所示的氨基酸序列或SEQ ID NO：1所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及由氨基酸组成的轻链可变区 SEQ ID NO：61所示的酸序列或SEQ ID NO：61所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及用于预防或治疗涉及 人α9整合素在其发病机制中，其使用抗体。
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公开(公告)号：US20110014213A1
公开(公告)日：2011-01-20
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译： 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段， 编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。
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公开(公告)号：US08715655B2
公开(公告)日：2014-05-06
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/46 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译： 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段， 编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。
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6.发明授权Lens driving apparatus, optical apparatus and control method for lens driving apparatus 有权透镜驱动装置，光学装置及透镜驱动装置的控制方法公开(公告)号：US08780455B2
公开(公告)日：2014-07-15
申请号：US12643877
申请日：2009-12-21
申请人： Daisuke Ishikawa
发明人： Daisuke Ishikawa
IPC分类号： G02B15/14
CPC分类号： G02B7/102 , G03B5/00 , H04N5/2254 , H04N5/23212 , H04N5/23296
摘要： The lens driving apparatus moves a magnification-varying lens and moves a focus lens to compensate for image plane variation caused by movement of the magnification-varying lens. The apparatus includes a zoom operating member, a stepping motor, a zoom controller controlling drive of the stepping motor, a focus actuator moving the focus lens, a focus controller controlling drive of the focus actuator, a memory storing cam data to compensate for the image plane variation, and a zoom position detector. During a magnification variation operation, the zoom controller performs open-loop control of the drive of the stepping motor based on an operation amount of the zoom operating member, and the focus controller controls the drive of the focus actuator based on the actual position of the magnification-varying lens detected by the zoom position detector, and the cam data.
摘要翻译： 透镜驱动装置移动变倍透镜并移动聚焦透镜以补偿由放大率变化透镜的移动引起的图像平面变化。 该装置包括变焦操作构件，步进电机，控制步进电机驱动的变焦控制器，移动聚焦透镜的聚焦致动器，控制聚焦致动器驱动的聚焦控制器，存储凸轮数据以补偿图像的存储器 平面变化和变焦位置检测器。 在放大变化操作期间，变焦控制器基于变焦操作构件的操作量执行对步进电动机的驱动的开环控制，并且焦点控制器基于实际位置来控制聚焦致动器的驱动 由变焦位置检测器检测的变倍透镜和摄像机数据。
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公开(公告)号：US08692894B2
公开(公告)日：2014-04-08
申请号：US12946066
申请日：2010-11-15
申请人： Tatsuya Yamazaki , Masahiro Shibata , Yoshikazu Ishikawa , Kazunori Ishii , Hideo Kawahara , Hitoshi Yasuda , Daisuke Ishikawa
发明人： Tatsuya Yamazaki , Masahiro Shibata , Yoshikazu Ishikawa , Kazunori Ishii , Hideo Kawahara , Hitoshi Yasuda , Daisuke Ishikawa
CPC分类号： G01B11/272 , G03B5/00 , G03B17/18 , H04N5/232 , H04N5/23222 , H04N5/23248 , H04N5/23254 , H04N5/23258 , H04N5/23264 , H04N5/23293 , H04N5/77 , H04N5/772 , H04N5/907 , H04N7/025 , H04N9/7921
摘要： An image pickup apparatus is disclosed which provides an appropriate inclination guide display in accordance with an aspect ratio of a picked-up image and the like. The image pickup apparatus includes an inclination detector which detects an inclination of the image pickup apparatus, a display device capable of superimposedly showing an inclination guide display corresponding to a detection output from the inclination detector, on a picked-up image, and an aspect ratio setter which sets the aspect ratio of a picked-up image. The apparatus includes a display controller which controls whether or not to show the inclination guide display on the display device on the basis of the aspect ratio set by the aspect ratio setter.
摘要翻译： 公开了一种根据拾取图像的纵横比等提供适当的倾斜引导显示的图像拾取装置。 图像拾取装置包括：倾斜检测器，其检测图像拾取装置的倾斜;能够叠加地显示与倾斜检测器的检测输出相对应的倾斜引导显示在显示图像上的显示装置，以及纵横比 设置拾取图像的纵横比的设置器。 该装置包括：显示控制器，其根据由纵横比设定器设定的纵横比来控制是否在显示装置上显示倾斜指示显示。
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公开(公告)号：US20120081498A1
公开(公告)日：2012-04-05
申请号：US13245656
申请日：2011-09-26
CPC分类号： B41J2/45 , G03G15/04063
摘要： Generally, according to an embodiment, a light-emitting panel includes a substrate and a light-emitting unit. The substrate is extended in a first direction. The light-emitting units are a plurality of light-emitting units that is in line in the first direction and comprises a light-emitting surface of which a length of a second direction that is orthogonal to the first direction is shorter than a length of the first direction.
摘要翻译： 通常，根据实施例，发光面板包括基板和发光单元。 基板沿第一方向延伸。 发光单元是在第一方向上成直线的多个发光单元，包括与第一方向正交的第二方向的长度短于第一方向的长度的发光面 第一个方向
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公开(公告)号：US20110242252A1
公开(公告)日：2011-10-06
申请号：US13069267
申请日：2011-03-22
CPC分类号： B41J2/45
摘要： According to one embodiment, an optical head includes a light emitting substrate emitting light and a heat sink including a contact section in contact with an area different from a light emitting area of the light emitting substrate and a deformable section separated from the light emitting substrate and deformed according to thermal expansion of the light emitting substrate.
摘要翻译： 根据一个实施例，光头包括发光的发光基板和散热器，散热器包括与不同于发光基板的发光区域的区域接触的接触部分和与发光基板分离的可变形部分， 根据发光基板的热膨胀而变形。
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公开(公告)号：US08022995B2
公开(公告)日：2011-09-20
申请号：US12044497
申请日：2008-03-07
申请人： Tatsuya Yamazaki , Masahiro Shibata , Yoshikazu Ishikawa , Kazunori Ishii , Hideo Kawahara , Hitoshi Yasuda , Daisuke Ishikawa
发明人： Tatsuya Yamazaki , Masahiro Shibata , Yoshikazu Ishikawa , Kazunori Ishii , Hideo Kawahara , Hitoshi Yasuda , Daisuke Ishikawa
CPC分类号： G01B11/272 , G03B5/00 , G03B17/18 , H04N5/232 , H04N5/23222 , H04N5/23248 , H04N5/23254 , H04N5/23258 , H04N5/23264 , H04N5/23293 , H04N5/77 , H04N5/772 , H04N5/907 , H04N7/025 , H04N9/7921
摘要： An image pickup apparatus is disclosed which provides an appropriate inclination guide display in accordance with an aspect ratio of a picked-up image and the like. The image pickup apparatus includes an inclination detector which detects an inclination of the image pickup apparatus, a display device capable of superimposedly showing an inclination guide display corresponding to a detection output from the inclination detector, on a picked-up image, and an aspect ratio setter which sets the aspect ratio of a picked-up image. The apparatus includes a display controller which controls whether or not to show the inclination guide display on the display device on the basis of the aspect ratio set by the aspect ratio setter.
摘要翻译： 公开了一种根据拾取图像的纵横比等提供适当的倾斜引导显示的图像拾取装置。 图像拾取装置包括：倾斜检测器，其检测图像拾取装置的倾斜;能够叠加地显示与倾斜检测器的检测输出相对应的倾斜引导显示在显示图像上的显示装置，以及纵横比 设置拾取图像的纵横比的设置器。 该装置包括：显示控制器，其根据由纵横比设定器设定的纵横比来控制是否在显示装置上显示倾斜指示显示。
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