-
公开(公告)号:US07241873B2
公开(公告)日:2007-07-10
申请号:US10489866
申请日:2002-09-25
申请人: Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
发明人: Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
CPC分类号: C07K14/52 , A61K39/00 , A61K2039/505 , C07K16/24 , C07K16/2842 , C07K16/2848 , C07K2317/34
摘要: A recombinant antibody in which at least the constant regions in the heavy chain and the light chain have been converted into human-origin regions and which inhibits the binding of an integrin recognizing the RGD sequence to osteopontin or its fragment and inhibits the binding of an integrin recognizing the SVVYGLR sequence or a sequence corresponding thereto to osteopontin or its fragment. This antibody is useful as a remedy for autoimmune diseases and a remedy for rheumatism or rheumatoid arthritis. Thus, a method of treating autoimmune diseases, rheumatism or rheumatoid arthritis is provided. This osteopontin antibody is useful in a diagnostic for rheumatism and a method of diagnosing rheumatism too.
摘要翻译: 重组抗体,其中至少重链和轻链中的恒定区已转化为人源区,并且抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合并抑制整联蛋白的结合 识别SVVYGLR序列或与骨桥蛋白或其片段相应的序列。 该抗体可用作自身免疫性疾病的补救剂和风湿病或类风湿性关节炎的治疗剂。 因此,提供了治疗自身免疫疾病,风湿病或类风湿性关节炎的方法。 该骨桥蛋白抗体可用于风湿病的诊断和风湿病的诊断方法。
-
公开(公告)号:US06833353B1
公开(公告)日:2004-12-21
申请号:US09786359
申请日:2001-03-14
IPC分类号: A61K3800
CPC分类号: A61K38/13 , A61K31/00 , A61K31/436 , Y10S514/886
摘要: A new use of immunosuppressant for treating or preventing MMp-medicated diseases is provided. The preferred immunosuppresants are tacrolimus, cyclosporing A or 33-epi-chloro-33-desoxyascomycin (pimecrolimus). Particularly, preferable MMP-mediated diseases are the diseases or conditions caused by gelatinase and/or collagenase, and/or inflammatory diseases concerned with gelatinase; such as arthritis (e.g., osteoarthritis, rheumatoid arthritis, etc.) cerebral diseases (e.g., stroke, etc.), tissue ulceration (e.g., corneal, epidermal and gastriculceration, etc.), abnormal wound healing, periodontal diseases, bone diseases (e.g., Paget's diseases, osteoporosis. etc.), tumor growth, tumor metastasis or invasion, HIV-infection, decubitus, decubitis ulcer, restenosis, epidermolysis bullosa, sepsis, septic shock, neoplasm, psoriasis, neovascularization and multiple sclerosis.
摘要翻译: 提供了一种新的免疫抑制剂用于治疗或预防MMP药物疾病的新用途。 优选的免疫抑制剂是他克莫司,环孢菌素A或33-表氯-3-脱氧菌丝霉素(吡美莫司)。 特别地,优选的MMP介导的疾病是由明胶酶和/或胶原酶引起的疾病或病症,和/或与明胶酶相关的炎性疾病; 例如关节炎(例如骨关节炎,类风湿性关节炎等)脑疾病(例如中风等),组织溃疡(例如角膜,表皮和胃溃疡等),异常伤口愈合,牙周病,骨病( 例如佩吉特氏病,骨质疏松症等),肿瘤生长,肿瘤转移或侵袭,HIV感染,褥疮,褥疮性溃疡,再狭窄,大疱性表皮松解,败血症,败血性休克,肿瘤,牛皮癣,新生血管形成和多发性硬化。
-
公开(公告)号:US20110014213A1
公开(公告)日:2011-01-20
申请号:US12810939
申请日:2008-12-26
申请人: Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人: Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
CPC分类号: C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要: The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译: 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段,抑制与其配体的相互作用,特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段, 编码抗体或抗体片段的基因,含有该基因的重组表达载体,携带该基因的转化体,使用该转化体的人抗α9整联蛋白抗体的制备方法或抗体片段,以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。
-
公开(公告)号:US08603476B2
公开(公告)日:2013-12-10
申请号:US12812341
申请日:2009-01-09
申请人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号: A61K39/395
CPC分类号: C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译: 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体,即包含重链可变区的人源化抗人α9整联蛋白抗体,其包含 的SEQ ID NO:11所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO:13所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO:15所示的氨基酸序列和由SEQ ID NO:9所示的氨基酸序列组成的轻链可变区,以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。
-
公开(公告)号:US20090053212A1
公开(公告)日:2009-02-26
申请号:US11755671
申请日:2007-05-30
申请人: Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
发明人: Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
CPC分类号: C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要: The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.
摘要翻译: 本发明提供具有比常规的更好的活性(抗原结合活性,白细胞迁移抑制活性等)和/或稳定性(耐热,低pH条件,变性剂等)的人源化抗人骨桥蛋白抗体 抗人骨桥蛋白抗体。
-
公开(公告)号:US08715655B2
公开(公告)日:2014-05-06
申请号:US12810939
申请日:2008-12-26
申请人: Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人: Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号: A61K39/395 , C07K16/00 , C07K16/46 , C07K16/28 , G01N33/53
CPC分类号: C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要: The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译: 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段,抑制与其配体的相互作用,特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段, 编码抗体或抗体片段的基因,含有该基因的重组表达载体,携带该基因的转化体,使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段,以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。
-
公开(公告)号:US20110059077A1
公开(公告)日:2011-03-10
申请号:US12812341
申请日:2009-01-09
申请人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
CPC分类号: C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译: 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体,即包含重链可变区的人源化抗人α9整联蛋白抗体,其包含 的SEQ ID NO:11所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,含有重链可变区的人源化抗人α9整联蛋白抗体由 由SEQ ID NO:13所示的氨基酸序列和由SEQ ID NO:17所示的氨基酸序列组成的轻链可变区,包含由SEQ ID NO:17所示的重链可变区组成的人源化抗人α9整联蛋白抗体 由SEQ ID NO:15所示的氨基酸序列和由SEQ ID NO:9所示的氨基酸序列组成的轻链可变区,以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中,其使用抗体。
-
公开(公告)号:US20110014193A1
公开(公告)日:2011-01-20
申请号:US12812368
申请日:2009-07-09
申请人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人: Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
CPC分类号: C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.
摘要翻译: 本发明提供了与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体,即人源化抗人α9整联蛋白抗体,其包含由以下组成的重链可变区: SEQ ID NO:1所示的氨基酸序列或SEQ ID NO:1所示的氨基酸序列,其中一个或几个氨基酸被取代,缺失,插入和/或添加,以及由氨基酸组成的轻链可变区 SEQ ID NO:61所示的酸序列或SEQ ID NO:61所示的氨基酸序列,其中一个或几个氨基酸被取代,缺失,插入和/或添加,以及用于预防或治疗涉及 人α9整合素在其发病机制中,其使用抗体。
-
公开(公告)号:US07807161B2
公开(公告)日:2010-10-05
申请号:US11755671
申请日:2007-05-30
申请人: Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
发明人: Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
IPC分类号: A61K39/00 , A61K39/395 , C07K16/46 , C07K16/24
CPC分类号: C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要: The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.
摘要翻译: 本发明提供具有比常规的更好的活性(抗原结合活性,白细胞迁移抑制活性等)和/或稳定性(耐热,低pH条件,变性剂等)的人源化抗人骨桥蛋白抗体 抗人骨桥蛋白抗体。
-
公开(公告)号:US20080069815A1
公开(公告)日:2008-03-20
申请号:US11836078
申请日:2007-08-08
申请人: Toshimitsu UEDE , Shigeyuki Kon , Yukihiko Saeki , Yasuyuki Yokosaki , Masaki Noda , Nobuchika Yamamoto
发明人: Toshimitsu UEDE , Shigeyuki Kon , Yukihiko Saeki , Yasuyuki Yokosaki , Masaki Noda , Nobuchika Yamamoto
IPC分类号: A61K39/00 , A61K39/395 , A61P19/02
CPC分类号: C07K14/52 , A61K39/00 , A61K2039/505 , C07K16/24 , C07K16/2842 , C07K16/2848 , C07K2317/34
摘要: An anti-osteopontin antibody which inhibits the binding of an integrin recognizing RGD sequence to osteopontin or its fragment, and which inhibits the binding of an integrin recognizing SVVYGLR sequence or sequence equivalent thereto to osteopontin or its fragment. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.
摘要翻译: 一种抗骨桥蛋白抗体,其抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合,并且其抑制识别SVVYGLR序列或等同于其的序列的整联蛋白与骨桥蛋白或其片段的结合。 该抗体可用于自身免疫性疾病的治疗,风湿病的治疗和类风湿性关节炎的治疗。 此外,提供了治疗自身免疫性疾病,风湿病或类风湿性关节炎的方法。 该抗体也可用于诊断和风湿病的诊断方法。
-
-
-
-
-
-
-
-
-