发明申请
US20110076305A1 EXTRACELLULAR MATRIX MATERIALS AS VACCINE ADJUVANTS FOR DISEASES ASSOCIATED WITH INFECTIOUS PATHOGENS OR TOXINS
有权
作为与感染性病原体或毒素相关的疾病的疫苗辅助物质的细胞基质材料
- 专利标题： EXTRACELLULAR MATRIX MATERIALS AS VACCINE ADJUVANTS FOR DISEASES ASSOCIATED WITH INFECTIOUS PATHOGENS OR TOXINS
- 专利标题（中）： 作为与感染性病原体或毒素相关的疾病的疫苗辅助物质的细胞基质材料
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申请号： US12868908申请日： 2010-08-26
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公开(公告)号： US20110076305A1公开(公告)日： 2011-03-31
- 发明人: Mark A. Suckow , William R. Wolter , Paul J. Hall
- 申请人： Mark A. Suckow , William R. Wolter , Paul J. Hall
- 申请人地址： US IN Notre Dame US IN West Lafayette
- 专利权人： University of Notre Dame Du Lac,Cook Biotech, Inc.
- 当前专利权人： University of Notre Dame Du Lac,Cook Biotech, Inc.
- 当前专利权人地址： US IN Notre Dame US IN West Lafayette
- 主分类号： A61K39/08
- IPC分类号： A61K39/08 ; A61K47/42 ; A61K39/00 ; A61P31/04 ; A61P37/04
摘要：
Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.
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