公开(公告)号：US20110076305A1

公开(公告)日：2011-03-31

申请号：US12868908

申请日：2010-08-26

申请人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

发明人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

IPC分类号： A61K39/08 ,  A61K47/42 ,  A61K39/00 ,  A61P31/04 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/08 ,  A61K2039/55511 ,  A61K2039/55588 ,  Y02A50/41 ,  Y02A50/412

摘要： Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.

摘要翻译： 公开了可用于治疗和/或预防与感染性病原体（例如破伤风）相关的感染和疾病以及与生物毒素相关的疾病的疫苗和疫苗佐剂。 还提供了制备佐剂和含有佐剂的疫苗的方法。 还提供了用于疫苗接种/免疫动物免受感染和与感染性病原体相关疾病（例如破伤风）以及与生物毒素相关的其它疾病的方法。 呈现从细胞外基质材料制备的辅助材料。 佐剂也可以描述为异源无细胞胶原组织制剂。 证明佐剂增强感兴趣的病原体抗原或感兴趣的生物毒素抗原的免疫原性，以及增强免疫动物的存活。

公开(公告)号：US09220770B2

公开(公告)日：2015-12-29

申请号：US12868908

申请日：2010-08-26

申请人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

发明人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/08

CPC分类号： A61K39/39 ,  A61K39/08 ,  A61K2039/55511 ,  A61K2039/55588 ,  Y02A50/41 ,  Y02A50/412

摘要： Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.

摘要翻译： 公开了可用于治疗和/或预防与感染性病原体（例如破伤风）相关的感染和疾病以及与生物毒素相关的疾病的疫苗和疫苗佐剂。 还提供了制备佐剂和含有佐剂的疫苗的方法。 还提供了用于疫苗接种/免疫动物免受感染和与感染性病原体相关疾病（例如破伤风）以及与生物毒素相关的其它疾病的方法。 呈现从细胞外基质材料制备的辅助材料。 佐剂也可以描述为异源无细胞胶原组织制剂。 证明佐剂增强感兴趣的病原体抗原或感兴趣的生物毒素抗原的免疫原性，以及增强免疫动物的存活。

公开(公告)号：US20100136050A1

公开(公告)日：2010-06-03

申请号：US12578359

申请日：2009-10-13

申请人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

发明人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

IPC分类号： A61K39/12 ,  A61K39/08 ,  A61K39/145 ,  A61K39/125 ,  A61K39/09 ,  A61K39/05 ,  A61K39/085

CPC分类号： A61K39/39 ,  A61K39/08 ,  A61K2039/55511 ,  A61K2039/55588 ,  Y02A50/41 ,  Y02A50/412

摘要： Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogenicity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.

摘要翻译： 公开了可用于治疗和/或预防与感染性病原体（例如破伤风）相关的感染和疾病以及与生物毒素相关的疾病的疫苗和疫苗佐剂。 还提供了制备佐剂和含有佐剂的疫苗的方法。 还提供了用于疫苗接种/免疫动物免受感染和与感染性病原体相关疾病（例如破伤风）以及与生物毒素相关的其它疾病的方法。 呈现从细胞外基质材料制备的辅助材料。 证明佐剂增强感染性病原体抗原或感兴趣的生物毒素抗原的免疫原性，以及增强免疫动物的存活。

公开(公告)号：US20090142400A1

公开(公告)日：2009-06-04

申请号：US12130432

申请日：2008-05-30

申请人： Michael C. Hiles ,  Paul J. Hall

发明人： Michael C. Hiles ,  Paul J. Hall

IPC分类号： A61K9/14 ,  A61K31/167 ,  A61K31/445 ,  A61P29/00

CPC分类号： A61L27/54 ,  A61L15/40 ,  A61L15/44 ,  A61L27/3604 ,  A61L27/3629 ,  A61L2300/402

摘要： Described are medical products including an analgesic such as lidocaine, bupivicaine, or a mixture thereof. Such medical products can find use in pain relief, particularly after surgery, and can be applied to tissue or can be implanted within a patient. Also described are medical products including an extracellular matrix material, one or more analgesic agents, and a carrier effective to extend the release of the agent(s). Related methods of manufacture and use are also described.

摘要翻译： 描述了包括止痛剂如利多卡因，布比卡因或其混合物的医疗产品。 这样的医疗产品可以用于疼痛缓解，特别是在手术之后，并且可以应用于组织或可以植入患者体内。 还描述了包括细胞外基质材料，一种或多种止痛剂和有效延长试剂释放的载体的医疗产品。 还描述了相关的制造和使用方法。

公开(公告)号：US20090092651A1

公开(公告)日：2009-04-09

申请号：US12236751

申请日：2008-09-24

申请人： Bhavin Shah ,  Paul J. Hall

发明人： Bhavin Shah ,  Paul J. Hall

IPC分类号： A61B17/12 ,  A61K35/38 ,  A61F2/00 ,  B32B7/14

CPC分类号： A61L27/3633 ,  A61L24/104 ,  A61L27/34 ,  A61L27/3629 ,  C08L89/06

摘要： Described are medical products including an adhesive containing a polypeptide component such as gelatin and a tackiness-providing polyhydroxy compound, such as at least one compound selected from the group consisting of glycerin and fructose. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Other medical applications utilizing a medical product of the invention include tissue repair and pharmaceutical delivery to a desired location. Related methods of manufacture and use are also described.

摘要翻译： 描述了包括含有多肽成分如明胶和提供粘性的多羟基化合物的粘合剂的医疗产品，例如选自甘油和果糖中的至少一种化合物。 这样的医疗产品可以用作与诸如吻合器的手术紧固装置结合使用的枕垫材料。 利用本发明的医疗产品的其它医疗应用包括组织修复和药物递送到期望的位置。 还描述了相关的制造和使用方法。