发明申请
- 专利标题： Modulation of T cell Differentiation for the treatment of T helper cell mediated diseases
- 专利标题（中）： 调节T细胞分化治疗T辅助细胞介导的疾病
-
申请号： US12437452申请日： 2009-05-07
-
公开(公告)号： US20110097325A1公开(公告)日： 2011-04-28
- 发明人: Frederic J. de Sauvage , Iqbal Grewal , Austin L. Gurney
- 申请人： Frederic J. de Sauvage , Iqbal Grewal , Austin L. Gurney
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N5/0783 ; A61K31/7105 ; A61K38/00 ; G01N33/53 ; A61K31/711 ; A61P37/02 ; A61P31/04 ; A61P31/10
摘要：
The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype, based on the relative expression levels of the gene TCCR, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.