发明申请
US20110098309A1 METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS
审中-公开
使用丙烯酸酯化合物抑制淀粉酶-β可扩散配体形成的方法
- 专利标题： METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS
- 专利标题（中）： 使用丙烯酸酯化合物抑制淀粉酶-β可扩散配体形成的方法
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申请号： US12668174申请日： 2008-07-11
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公开(公告)号： US20110098309A1公开(公告)日： 2011-04-28
- 发明人: Gary Charles Look , Lauri Schultz , Alexandre Mikhaylovich Polozov , Nikhil Bhagat , Jian Wang , David E. Zembower , William F. Goure , Todd Pray , Grant A. Krafft
- 申请人： Gary Charles Look , Lauri Schultz , Alexandre Mikhaylovich Polozov , Nikhil Bhagat , Jian Wang , David E. Zembower , William F. Goure , Todd Pray , Grant A. Krafft
- 申请人地址： US CA Livermore
- 专利权人： ACUMEN PHARMACEUTICALS, INC.
- 当前专利权人： ACUMEN PHARMACEUTICALS, INC.
- 当前专利权人地址： US CA Livermore
- 国际申请： PCT/US08/69878 WO 20080711
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; C12N5/071 ; A61K31/16 ; A61K31/343 ; A61K31/341 ; A61K31/381 ; A61K31/40 ; C07C233/00 ; C07D333/56 ; C07D333/22 ; C07D207/30 ; C07D241/04 ; C07D307/02 ; A61P25/28
摘要：
Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers from amyloid β1-42 monomers using acylhydrazide compounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers using acylhydrazide compounds.