发明申请
- 专利标题： Diaminoalkane aspartic protease inhibitors
- 专利标题（中）： 二氨基烷烃天冬氨酸蛋白酶抑制剂
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申请号： US12802142申请日： 2010-05-28
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公开(公告)号： US20110105506A1公开(公告)日： 2011-05-05
- 发明人: John J. Baldwin , David A. Claremon , Colin M. Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Wei Zhao , Robert D. Simpson , Suresh B. Singh , Patrick T. Flaherty , Jean-Pierre Wery
- 申请人： John J. Baldwin , David A. Claremon , Colin M. Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Wei Zhao , Robert D. Simpson , Suresh B. Singh , Patrick T. Flaherty , Jean-Pierre Wery
- 专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人： Vitae Pharmaceuticals, Inc.
- 主分类号： A61K31/5375
- IPC分类号： A61K31/5375 ; C07D211/22 ; C07D417/04 ; C07D405/10 ; C07D211/60 ; A61K31/451 ; A61K31/445 ; A61K31/454 ; A61K31/4525 ; C07D265/30
摘要：
Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I.
公开/授权文献
- US08455521B2 Diaminoalkane aspartic protease inhibitors 公开/授权日：2013-06-04
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