发明申请
- 专利标题： Protein Kinase Conjugates and Inhibitors
- 专利标题（中）： 蛋白激酶结合物和抑制剂
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申请号： US12882484申请日： 2010-09-15
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公开(公告)号： US20110117073A1公开(公告)日： 2011-05-19
- 发明人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
- 申请人： Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
- 申请人地址： US MA Waltham
- 专利权人： Avila Therapeutics, Inc.
- 当前专利权人： Avila Therapeutics, Inc.
- 当前专利权人地址： US MA Waltham
- 主分类号： A61K38/45
- IPC分类号： A61K38/45 ; C12N9/12 ; C07D403/14 ; A61K31/497 ; C07D213/66 ; C07D239/42 ; C07D487/04 ; A61K31/502 ; A61K31/44 ; A61K31/506 ; A61P9/00 ; A61P35/00 ; A61P25/28 ; A61P19/00 ; A61P11/06 ; A61P37/02
摘要：
The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
公开/授权文献
- US09556426B2 Protein kinase conjugates and inhibitors 公开/授权日：2017-01-31
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