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公开(公告)号:US20110117073A1
公开(公告)日:2011-05-19
申请号:US12882484
申请日:2010-09-15
申请人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
发明人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
IPC分类号: A61K38/45 , C12N9/12 , C07D403/14 , A61K31/497 , C07D213/66 , C07D239/42 , C07D487/04 , A61K31/502 , A61K31/44 , A61K31/506 , A61P9/00 , A61P35/00 , A61P25/28 , A61P19/00 , A61P11/06 , A61P37/02
CPC分类号: C07D487/04 , A61K47/545 , A61K47/62 , C07D213/72 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/22 , C07D231/12 , C07D239/42 , C07D239/48 , C07D333/68 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D495/04 , C07D498/04 , C12N9/1205 , C12N9/96
摘要: The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
摘要翻译: 本发明涉及蛋白质缀合物,其含有包含ATP结合位点中的半胱氨酸残基的蛋白激酶和与所述半胱氨酸残基共价和不可逆地结合的抑制剂,使得蛋白激酶的活性不可逆地被抑制。 本发明还涉及不可逆地抑制蛋白激酶的化合物。
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公开(公告)号:US09556426B2
公开(公告)日:2017-01-31
申请号:US12882484
申请日:2010-09-15
申请人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
发明人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
IPC分类号: C12N9/96 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , A61K47/48 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/22 , C07D231/12 , C07D239/42 , C07D239/48 , C07D333/68 , C07D401/12 , C07D403/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D495/04 , C07D498/04 , C12N9/12
CPC分类号: C07D487/04 , A61K47/545 , A61K47/62 , C07D213/72 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/22 , C07D231/12 , C07D239/42 , C07D239/48 , C07D333/68 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D495/04 , C07D498/04 , C12N9/1205 , C12N9/96
摘要: The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
摘要翻译: 本发明涉及含有ATP结合位点中含有半胱氨酸残基的蛋白激酶和与所述半胱氨酸残基共价和不可逆地结合的抑制剂的蛋白质缀合物,使得蛋白激酶的活性不可逆地被抑制。 本发明还涉及不可逆地抑制蛋白激酶的化合物。
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公开(公告)号:US20100069294A1
公开(公告)日:2010-03-18
申请号:US12497103
申请日:2009-07-02
申请人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
发明人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
CPC分类号: A61K47/48246 , A61K38/00 , A61K38/005 , A61K38/06 , A61K38/12 , A61K47/64 , C07D401/12 , C07K5/0202 , C07K5/06165 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C12N9/506 , C12N9/96 , C12Y304/00
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号:US08309685B2
公开(公告)日:2012-11-13
申请号:US12497103
申请日:2009-07-02
申请人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
发明人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
IPC分类号: C07K5/08
CPC分类号: A61K47/48246 , A61K38/00 , A61K38/005 , A61K38/06 , A61K38/12 , A61K47/64 , C07D401/12 , C07K5/0202 , C07K5/06165 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C12N9/506 , C12N9/96 , C12Y304/00
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译: 本发明提供化合物,其药学上可接受的组合物及其使用方法。
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公开(公告)号:US20090306085A1
公开(公告)日:2009-12-10
申请号:US12339680
申请日:2008-12-19
申请人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
发明人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
IPC分类号: A61K31/4709 , C07D215/233 , C07D471/22 , C07D241/52 , A61K31/4745 , A61K31/498 , A61P31/12
CPC分类号: A61K38/06 , A61K38/00 , A61K38/05 , A61K38/12 , C07K5/06165 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0827 , C07K5/12
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号:US09163061B2
公开(公告)日:2015-10-20
申请号:US12339680
申请日:2008-12-19
申请人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
发明人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
CPC分类号: A61K38/06 , A61K38/00 , A61K38/05 , A61K38/12 , C07K5/06165 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0827 , C07K5/12
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译: 本发明提供化合物,其药学上可接受的组合物及其使用方法。
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公开(公告)号:US20110269244A1
公开(公告)日:2011-11-03
申请号:US12982352
申请日:2010-12-30
申请人: Russell C. Petter , Charles F. Jewell , Kwangho Lee , Aravind Prasad Medikonda , Deqiang Niu , Lixin Qiao , Juswinder Singh , Zhendong Zhu
发明人: Russell C. Petter , Charles F. Jewell , Kwangho Lee , Aravind Prasad Medikonda , Deqiang Niu , Lixin Qiao , Juswinder Singh , Zhendong Zhu
CPC分类号: C12N9/96 , C07D207/16 , C07D239/49 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/06 , C07D417/14 , C07D487/04 , C07D491/08 , C07D493/04 , C07D495/04 , C07D513/04 , C07D519/00 , C12N9/12 , C12N9/506 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/485 , C12Y207/11001 , C12Y304/21098 , C12Y603/02 , G01N33/68 , G16B15/00 , G16C20/50
摘要: The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
摘要翻译: 本发明涉及酶抑制剂。 更具体地,本发明涉及蛋白质的配体定向共价修饰; 设计方法 药物制剂相同; 和使用方法。
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公开(公告)号:US08778877B2
公开(公告)日:2014-07-15
申请号:US12339770
申请日:2008-12-19
申请人: Deqiang Niu , Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Lixin Qiao
发明人: Deqiang Niu , Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Lixin Qiao
CPC分类号: C07D487/16 , A61K31/4035 , A61K31/407 , A61K31/506 , A61K38/00 , A61K45/06 , C07D403/12 , C07D403/14 , C07D487/04 , C07K5/06165 , C07K5/0806 , C07K5/0812 , C07K5/0827
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号:US20130017991A1
公开(公告)日:2013-01-17
申请号:US13620573
申请日:2012-09-14
申请人: Deqiang Niu , Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Lixin Qiao
发明人: Deqiang Niu , Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Lixin Qiao
CPC分类号: C07K5/081 , A61K38/00 , C07K5/0202 , C07K5/06165 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C12N9/506 , C12N9/96 , C12N9/99
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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公开(公告)号:US20120190614A1
公开(公告)日:2012-07-26
申请号:US13443847
申请日:2012-04-10
申请人: Deqiang Niu , Russell C. Petter , Lixin Qiao , Juswinder Singh
发明人: Deqiang Niu , Russell C. Petter , Lixin Qiao , Juswinder Singh
IPC分类号: A61K38/06 , C07K5/107 , C07K5/083 , A61P31/12 , A61K38/07 , C12N9/96 , A61P31/14 , C07K5/09 , C07K5/023
CPC分类号: C07K7/06 , A61K31/40 , A61K31/403 , A61K31/4439 , A61K31/4965 , A61K31/506 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/52 , C07D401/12 , C07D403/12 , C07K5/06165 , C07K5/0802 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/0821 , C07K5/0827 , C07K5/1016 , C12N9/506 , C12N9/99 , C12Y304/21098
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译: 本发明提供化合物,其药学上可接受的组合物及其使用方法。
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