发明申请
- 专利标题： PCSK9 INHIBITORS AND METHODS OF USE THEREOF
- 专利标题（中）： PCSK9抑制剂及其使用方法
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申请号： US12994835申请日： 2009-06-01
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公开(公告)号： US20110118181A1公开(公告)日： 2011-05-19
- 发明人: Nabil G. Seidah , Gaétan Mayer , Steve Poirier
- 申请人： Nabil G. Seidah , Gaétan Mayer , Steve Poirier
- 申请人地址： CA QC MONTREAL
- 专利权人： INSTITUT DE RECHERHES CLINIQUES DE MONTREAL
- 当前专利权人： INSTITUT DE RECHERHES CLINIQUES DE MONTREAL
- 当前专利权人地址： CA QC MONTREAL
- 国际申请： PCT/CA09/00764 WO 20090601
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C12Q1/68 ; G01N33/68 ; C12N5/071 ; C07K14/47 ; C07K16/18 ; C07H21/00 ; C12N15/63 ; C12N5/10 ; A61P3/00
摘要：
A method for identifying a compound for preventing or treating a LDLR-associated disease, a VLDLR-associated disease or an ApoER2-associated disease, said method comprising determining whether: a) a level of expression of Annexin A2 nucleic acid or encoded polypeptide; b) a level of Annexin A2 activity; or c) a combination of a) and b), is increased in the presence of a test compound relative to in the absence of said test compound, wherein said increase is indicative that said test compound can be used for preventing or treating a LDLR-associated disease, a VLDLR-associated disease, an ApoER2-associated disease.
公开/授权文献
- US08673850B2 PCSK9 inhibitors and methods of use thereof 公开/授权日：2014-03-18
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