发明申请
- 专利标题： BETA-SECRETASE MODULATORS AND METHODS OF USE
- 专利标题（中）： BETA-SECRETASE调制器和使用方法
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申请号： US12909566申请日： 2010-10-21
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公开(公告)号： US20110118250A1公开(公告)日： 2011-05-19
- 发明人: Brian K. Albrecht , Denise Lyn Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart C. Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod F. Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang , Wenge Zhong
- 申请人： Brian K. Albrecht , Denise Lyn Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart C. Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod F. Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang , Wenge Zhong
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 主分类号： A61K31/538
- IPC分类号： A61K31/538 ; C07D405/12 ; A61K31/4433 ; A61K31/444 ; C07D405/14 ; A61K31/4439 ; A61K31/506 ; A61K31/497 ; C07D413/12 ; A61K31/5377 ; A61K31/4178 ; A61K31/4545 ; A61K31/453 ; C07D311/96 ; A61K31/352 ; C07D407/12 ; A61K31/4709 ; C07D401/12 ; C07D409/12 ; A61K31/422 ; A61K31/4025 ; C07D471/04 ; A61K31/501 ; A61P25/28 ; A61P25/00 ; A61P25/16
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
公开/授权文献
- US08163766B2 Beta-secretase modulators and methods of use 公开/授权日：2012-04-24
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