发明申请
US20110129458A1 BINDING MOLECULES WITH MULTIPLE BINDING SITES, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
审中-公开
具有多个结合位点的结合分子，包含它们的组合物及其用途
- 专利标题： BINDING MOLECULES WITH MULTIPLE BINDING SITES, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
- 专利标题（中）： 具有多个结合位点的结合分子，包含它们的组合物及其用途
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申请号： US12676705申请日： 2007-12-17
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公开(公告)号： US20110129458A1公开(公告)日： 2011-06-02
- 发明人: Edward Dolk , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee De Bruin
- 申请人： Edward Dolk , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee De Bruin
- 申请人地址： BE Ghent-Zwijnaarde
- 专利权人： Ablynx N.V.
- 当前专利权人： Ablynx N.V.
- 当前专利权人地址： BE Ghent-Zwijnaarde
- 国际申请： PCT/EP2007/064063 WO 20071217
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; C07K16/00 ; C07H21/00 ; C12N5/10 ; C12P21/00 ; A61P37/02
摘要：
The present invention relates to binding molecules, such as amino acid sequences with multiple antigen binding sites. In particular, the binding molecules of the present invention have at least two antigen binding sites that partially or fully overlap with each other and that are directed against at least two different naturally occurring binding molecules. The invention further relates to uses of such binders, for example in methods for inhibiting and/or blocking of the interaction between said at least two naturally occurring binding molecules and a third naturally occurring binding molecule.
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