发明申请
- 专利标题： Constructs and Methods for the Production and Secretion of Polypeptides
- 专利标题（中）： 多肽生产和分泌的构建和方法
-
申请号： US13056352申请日： 2009-07-30
-
公开(公告)号： US20110129876A1公开(公告)日： 2011-06-02
- 发明人: Henri-Pierre Fierobe , Florence Mingardon , Angélique Chanal-Vial
- 申请人： Henri-Pierre Fierobe , Florence Mingardon , Angélique Chanal-Vial
- 申请人地址： FR Courbevoie FR Paris, Cedex 16 FR Marseille, Cedex 7 FR Marseille, Cedex 3 FR Toulouse, Cedex 4
- 专利权人： Total S.A.,Le Centre National De Recherche Scientifique (CNRS),L'Universite de la Mediterranee,L'Universite de Provence,L'Instutut National des Sciences Appliquees (INSA)
- 当前专利权人： Total S.A.,Le Centre National De Recherche Scientifique (CNRS),L'Universite de la Mediterranee,L'Universite de Provence,L'Instutut National des Sciences Appliquees (INSA)
- 当前专利权人地址： FR Courbevoie FR Paris, Cedex 16 FR Marseille, Cedex 7 FR Marseille, Cedex 3 FR Toulouse, Cedex 4
- 优先权： EP08290739.5 20080731; EP08291120.7 20081128
- 国际申请： PCT/EP2009/059875 WO 20090730
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N1/21 ; C07H21/00 ; C12N9/42
摘要：
Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.
公开/授权文献
信息查询
