发明申请
US20110152528A1 Method For Producing 3,7-Diaza-Bicyclo[3.3.1] Nonane Compounds
有权
制备3,7-二氮杂双环[3.3.1]壬烷化合物的方法
![Method For Producing 3,7-Diaza-Bicyclo[3.3.1] Nonane Compounds](/docs/US/2011-06-23/US20110152528A1/abs.jpg.600x600.jpg)
- 专利标题： Method For Producing 3,7-Diaza-Bicyclo[3.3.1] Nonane Compounds
- 专利标题（中）： 制备3,7-二氮杂双环[3.3.1]壬烷化合物的方法
-
申请号： US13059470申请日： 2009-08-17
-
公开(公告)号： US20110152528A1公开(公告)日： 2011-06-23
- 发明人: Melanie Sajitz , Steve Laborda , Peter Naumann , Michael Wessling
- 申请人： Melanie Sajitz , Steve Laborda , Peter Naumann , Michael Wessling
- 申请人地址： VG Tortola
- 专利权人： CLARIANT FINANCE (BVI) LIMITED
- 当前专利权人： CLARIANT FINANCE (BVI) LIMITED
- 当前专利权人地址： VG Tortola
- 优先权： DE102008038376.7 20080819; EPPCT/EP2009/005937 20090817
- 国际申请： PCT/EP09/05937 WO 20090817
- 主分类号： C07D471/08
- IPC分类号： C07D471/08
![Method For Producing 3,7-Diaza-Bicyclo[3.3.1] Nonane Compounds](/abs-image/US/2011/06/23/US20110152528A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to a one-pot reaction for the production of 3,7-diaza-bicyclo[3.3.1]nonane compounds, wherein in a first step a dicarboxylic acid ester is reacted with a pyridine aldehyde and a primary amine. The piperidone created in this manner is reacted with formaldehyde and a further primary amine in a second step. It is essential to the invention that both reaction steps are carried out in a one-pot variation in a C1-C4 alcohol as the solvent, and that the reaction water created is removed by means of distillation.