发明申请
- 专利标题: COMPOSITIONS AND METHODS FOR INCREASING SERUM HALF-LIFE
- 专利标题(中): 用于增加血清半衰期的组合物和方法
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申请号: US12959220申请日: 2010-12-02
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公开(公告)号: US20110171218A1公开(公告)日: 2011-07-14
- 发明人: Jasbir Seehra , John Knopf , Ravindra Kumar
- 申请人: Jasbir Seehra , John Knopf , Ravindra Kumar
- 申请人地址: US MA Cambridge
- 专利权人: Acceleron Pharma Inc.
- 当前专利权人: Acceleron Pharma Inc.
- 当前专利权人地址: US MA Cambridge
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07H21/00 ; C12P21/00 ; C12N5/10 ; C07K19/00 ; A61P29/00 ; A61P37/06 ; A61P31/00 ; A61P31/04 ; A61P31/10 ; A61P31/12 ; A61P33/00 ; A61P25/28 ; A61P25/16 ; C12N1/00
摘要:
Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or more non-endogenous glycosylation sites.
公开/授权文献
- US08722615B2 Compositions and methods for increasing serum half-life 公开/授权日:2014-05-13
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