发明申请
- 专利标题: METHOD FOR PRODUCING PEPTIDE
- 专利标题(中): 生产肽的方法
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申请号: US12671238申请日: 2008-07-30
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公开(公告)号: US20110172392A1公开(公告)日: 2011-07-14
- 发明人: Yasuhiro Kajihara , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
- 申请人: Yasuhiro Kajihara , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
- 申请人地址: JP Osaka-shi
- 专利权人: OTSUKA CHEMICAL CO., LTD.
- 当前专利权人: OTSUKA CHEMICAL CO., LTD.
- 当前专利权人地址: JP Osaka-shi
- 优先权: JP2007-199372 20070731
- 国际申请: PCT/JP2008/063659 WO 20080730
- 主分类号: C07K1/113
- IPC分类号: C07K1/113
摘要:
The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an —SMe group; (b) allowing the —SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b).
公开/授权文献
- US08809258B2 Method for producing peptide 公开/授权日:2014-08-19