发明申请
- 专利标题： DUAL-ACTING ANTIHYPERTENSIVE AGENTS
- 专利标题（中）： 双作用抗菌剂
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申请号： US12949114申请日： 2010-11-18
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公开(公告)号： US20110230525A1公开(公告)日： 2011-09-22
- 发明人: Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Robert Murray McKinnell , Brooke Blair
- 申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Robert Murray McKinnell , Brooke Blair
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE, INC.
- 当前专利权人： THERAVANCE, INC.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/4164 ; A61K31/41 ; A61K31/4196 ; A61P13/12
摘要：
In one aspect, the invention relates to compounds having the formula: wherein: Ar, r, Z, X, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US08080572B2 Dual-acting antihypertensive agents 公开/授权日：2011-12-20
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