发明申请
US20110237585A1 SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
有权
取代的丙烯酰胆碱衍生物作为HISTONE脱乙酰壳多糖的新型抑制剂
- 专利标题： SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
- 专利标题（中）： 取代的丙烯酰胆碱衍生物作为HISTONE脱乙酰壳多糖的新型抑制剂
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申请号： US13048826申请日： 2011-03-15
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公开(公告)号： US20110237585A1公开(公告)日： 2011-09-29
- 发明人: Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
- 申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
- 申请人地址： BE BEERSE
- 专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人地址： BE BEERSE
- 优先权： EP04077171.9 20040728; EPPCT/EP2005/053611 20050725
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D403/04 ; A61K31/496 ; C07D403/14 ; C07D413/14 ; A61P35/00 ; A61P17/06
摘要：
This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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