专利检索 ap:"Laurence Françoise Bernadette Marconnet-Decrane" 第 1 页

1.

发明授权
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase 有权
标题翻译：吡啶和嘧啶衍生物作为组蛋白脱乙酰酶的抑制剂

公开(公告)号：US08114876B2

公开(公告)日：2012-02-14

申请号：US12160124

申请日：2007-01-16

申请人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud

发明人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud

IPC分类号： C07D239/42 , C07D403/12 , A61K31/506

CPC分类号： A61K31/496 , A61K45/06 , C07D213/78 , C07D213/82 , C07D239/42 , C07D403/12 , C07D409/14 , Y02A50/411

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

2.

发明申请
QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS 有权
标题翻译：喹诺酮衍生物作为PARP和油墨抑制剂

公开(公告)号：US20130018017A1

公开(公告)日：2013-01-17

申请号：US13617686

申请日：2012-09-14

申请人： Jorge Eduardo VIALARD , Patrick René ANGIBAUD , Laurence Anne MEVELLEC , Christophe MEYER , Eddy Jean Edgard FREYNE , Isabelle Noëlle Constance PILATTE , Bruno ROUX , Elizabeth Thérèse Jeanne PASQUIER , Xavier Marc BOURDREZ , Christophe Denis ADELINET , Laurence Françoise Bernadette MARCONNET-DECRANE , Jacqueline Anne MACRITCHIE , James Edward Stewart DUFFY , Andrew Pate OWENS , Pierre-Henri STORCK , Virginie Sophie PONCELET

发明人： Jorge Eduardo VIALARD , Patrick René ANGIBAUD , Laurence Anne MEVELLEC , Christophe MEYER , Eddy Jean Edgard FREYNE , Isabelle Noëlle Constance PILATTE , Bruno ROUX , Elizabeth Thérèse Jeanne PASQUIER , Xavier Marc BOURDREZ , Christophe Denis ADELINET , Laurence Françoise Bernadette MARCONNET-DECRANE , Jacqueline Anne MACRITCHIE , James Edward Stewart DUFFY , Andrew Pate OWENS , Pierre-Henri STORCK , Virginie Sophie PONCELET

IPC分类号： A61K31/4704 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/675 , A61K31/4709 , A61K31/501 , A61K31/475 , A61P25/00 , A61P25/28 , A61P9/00 , A61P21/00 , A61P29/00 , A61P19/06 , A61P19/02 , A61P9/10 , A61P37/00 , A61P35/00 , A61P1/00 , A61P19/10 , A61P3/10 , A61P13/12 , A61K31/695

CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06

摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.

摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有定义含义。

3.

发明授权
Quinolinone derivatives as PARP and TANK inhibitors 有权
标题翻译：喹啉酮衍生物作为PARP和TANK抑制剂

公开(公告)号：US08299256B2

公开(公告)日：2012-10-30

申请号：US12529142

申请日：2008-03-07

申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet

发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet

IPC分类号： C07D215/38

CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06

摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.

摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有定义含义。

4.

发明申请
SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译：取代的亚氨基哌啶或吗啉衍生物作为HISTONE脱乙酰酶的新型抑制剂

公开(公告)号：US20120157456A1

公开(公告)日：2012-06-21

申请号：US13302930

申请日：2011-11-22

申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte

发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte

IPC分类号： A61K31/5377 , A61P35/00 , C07D413/04 , C07D401/04 , A61K31/506

CPC分类号： C07D405/14 , C07D401/04

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

5.

发明授权
Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase 有权
标题翻译：取代的氨基丙烯基哌啶或吗啉衍生物作为组蛋白脱乙酰酶的新型抑制剂

公开(公告)号：US08138198B2

公开(公告)日：2012-03-20

申请号：US11914208

申请日：2006-05-16

申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte

发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Sven Franciscus Anna Van Brandt , Isabelle Noëlle Constance Pilatte

IPC分类号： A01N43/54 , A61K31/505 , C07D419/00

CPC分类号： C07D405/14 , C07D401/04

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

6.

发明授权
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase 有权
标题翻译：吡啶和嘧啶衍生物作为组蛋白脱乙酰酶的抑制剂

公开(公告)号：US08664223B2

公开(公告)日：2014-03-04

申请号：US13347338

申请日：2012-01-10

申请人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud

发明人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud

IPC分类号： C07D401/04 , A61K31/444

CPC分类号： A61K31/496 , A61K45/06 , C07D213/78 , C07D213/82 , C07D239/42 , C07D403/12 , C07D409/14 , Y02A50/411

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

7.

发明授权
Quinolinone derivatives as PARP inhibitors 有权
标题翻译：喹啉酮衍生物作为PARP抑制剂

公开(公告)号：US08404713B2

公开(公告)日：2013-03-26

申请号：US12681790

申请日：2008-10-22

申请人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Jorge Eduardo Vialard , Laurence Anne Mevellec , Christophe Meyer , Pierre-Henri Storck

发明人： Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Jorge Eduardo Vialard , Laurence Anne Mevellec , Christophe Meyer , Pierre-Henri Storck

IPC分类号： A61K31/04 , C07D215/38

CPC分类号： C07D215/227 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D487/08

摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, Z and n have defined meanings, the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary ammonium salts and the stereochemically isomeric forms thereof, and their use for the treatment of PARP-mediated disorders.

摘要翻译： 式（I）化合物：其中R1，R2，R3，R4，R5，Z和n具有定义的含义，N-氧化物形式，药学上可接受的加成盐，季铵盐及其立体化学异构形式，以及它们用于治疗PARP介导的病症。

8.

发明申请
SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译：取代的丙烯酰胆碱衍生物作为HISTONE脱乙酰壳多糖的新型抑制剂

公开(公告)号：US20110237585A1

公开(公告)日：2011-09-29

申请号：US13048826

申请日：2011-03-15

申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts

发明人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts

IPC分类号： A61K31/5377 , C07D403/04 , A61K31/496 , C07D403/14 , C07D413/14 , A61P35/00 , A61P17/06

CPC分类号： C07D239/42 , C07D239/54 , C07D403/12

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

9.

发明授权
Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase 有权
标题翻译：取代的丙烯基哌嗪衍生物作为组蛋白脱乙酰酶的新型抑制剂

公开(公告)号：US07947830B2

公开(公告)日：2011-05-24

申请号：US11626215

申请日：2007-01-23

申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts

发明人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts

IPC分类号： C07D417/00 , C07D413/00 , C07D403/00

CPC分类号： C07D239/42 , C07D239/54 , C07D403/12

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。