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1.发明申请SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权取代的丙烯酰胆碱衍生物作为HISTONE脱乙酰壳多糖的新型抑制剂公开(公告)号：US20110237585A1
公开(公告)日：2011-09-29
申请号：US13048826
申请日：2011-03-15
申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
发明人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
IPC分类号： A61K31/5377 , C07D403/04 , A61K31/496 , C07D403/14 , C07D413/14 , A61P35/00 , A61P17/06
CPC分类号： C07D239/42 , C07D239/54 , C07D403/12
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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2.发明授权Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase 有权取代的丙烯基哌嗪衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号：US07947830B2
公开(公告)日：2011-05-24
申请号：US11626215
申请日：2007-01-23
申请人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
发明人： Sven Franciscus Anna Van Brandt , Kristof Van Emelen , Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Janine Arts
IPC分类号： C07D417/00 , C07D413/00 , C07D403/00
CPC分类号： C07D239/42 , C07D239/54 , C07D403/12
摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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3.发明授权公开(公告)号：US08163733B2
公开(公告)日：2012-04-24
申请号：US12724273
申请日：2010-03-15
申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
IPC分类号： A61K31/55 , A61K31/4468 , A61K31/506 , A61K31/496
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：US07615553B2
公开(公告)日：2009-11-10
申请号：US10507785
申请日：2003-03-11
申请人： Kristof Van Emelen , Marc Gustaaf Celine Verdonck , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Lieven Meerpoel , Alexey Borisovich Dyatkin
发明人： Kristof Van Emelen , Marc Gustaaf Celine Verdonck , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Lieven Meerpoel , Alexey Borisovich Dyatkin
IPC分类号： C07D401/04 , C07D239/42 , A61K31/505
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括具有组蛋白脱乙酰酶抑制酶活性的新颖的式（I）化合物，其中n，R 1，R 2，R 3，R 4，Q，X，Y，Z具有定义的含义; 其制剂，含有它们的组合物及其作为药物的用途。
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5.发明授权公开(公告)号：US08513237B2
公开(公告)日：2013-08-20
申请号：US13425690
申请日：2012-03-21
申请人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
IPC分类号： A61K31/55 , A61K31/506 , A61K31/4545 , A61K31/5377 , C07D211/58 , C07D401/04 , C07D401/14 , C07D413/14
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：US08455498B2
公开(公告)日：2013-06-04
申请号：US12560657
申请日：2009-09-16
申请人： Kristof Van Emelen , Marc Gustaaf Celine Verdonck , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Lieven Meerpoel , Alexey Borisovich Dyatkin
发明人： Kristof Van Emelen , Marc Gustaaf Celine Verdonck , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Lieven Meerpoel , Alexey Borisovich Dyatkin
IPC分类号： C07D295/14 , A61K31/495
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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7.发明申请公开(公告)号：US20120178741A1
公开(公告)日：2012-07-12
申请号：US13425690
申请日：2012-03-21
申请人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noélle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noélle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
IPC分类号： A61K31/55 , A61K31/506 , A61K31/4545 , A61K31/5377 , C07D211/58 , C07D401/04 , C07D401/14 , C07D413/14 , A61P35/00 , A61P19/02 , A61P19/06 , A61P9/10 , A61P29/00 , A61P3/10 , A61P11/06 , A61P17/10 , A61P25/00 , A61P17/14 , A61P9/00 , A61P13/12 , A61P5/00 , A61P25/16 , A61P25/28 , A61K31/451
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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8.发明申请公开(公告)号：US20100234353A1
公开(公告)日：2010-09-16
申请号：US12724273
申请日：2010-03-15
申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
IPC分类号： A61K31/55 , C07D211/98 , A61K31/4468 , C07D239/32 , A61K31/506 , C07D401/14 , A61K31/496 , C07D401/04 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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9.发明授权公开(公告)号：US07767679B2
公开(公告)日：2010-08-03
申请号：US10507159
申请日：2003-03-11
申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I） 其制剂，含有它们的组合物及其作为药物的用途。
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公开(公告)号：US07709487B2
公开(公告)日：2010-05-04
申请号：US11668906
申请日：2007-01-30
申请人： Kristof Van Emelen , Janine Arts , Leo Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
发明人： Kristof Van Emelen , Janine Arts , Leo Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D207/277 , C07D207/28 , C07D211/14 , C07D211/58 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D217/16 , C07D233/90 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D261/10 , C07D295/155 , C07D295/22 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48 , G01N33/573 , G01N2333/91
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译： 本发明包括式（I）的新化合物，其中n，m，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。
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