发明申请
- 专利标题： DUAL-ACTING ANTIHYPERTENSIVE AGENTS
- 专利标题（中）： 双作用抗菌剂
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申请号： US13165975申请日： 2011-06-22
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公开(公告)号： US20110251249A1公开(公告)日： 2011-10-13
- 发明人: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Robert Murray McKinnell
- 申请人： Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Robert Murray McKinnell
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE, INC.
- 当前专利权人： THERAVANCE, INC.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; A61P9/12 ; A61P9/00 ; A61K31/4178 ; A61K31/4164
摘要：
The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US08227497B2 Dual-acting antihypertensive agents 公开/授权日：2012-07-24
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