发明申请
- 专利标题: METHOD FOR OBTAINING PANCREATIC PROGENITOR CELL USING NEPH3
- 专利标题(中): 使用NEPH3获得胰腺癌细胞的方法
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申请号: US13141063申请日: 2009-12-18
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公开(公告)号: US20110256548A1公开(公告)日: 2011-10-20
- 发明人: Yuichi Ono , Tomoya Nakatani , Yasuko Nakagawa
- 申请人: Yuichi Ono , Tomoya Nakatani , Yasuko Nakagawa
- 申请人地址: JP Tokyo
- 专利权人: Eisai R&D Management Co., Ltd.
- 当前专利权人: Eisai R&D Management Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2008-326401 20081222; JP2009-040667 20090224
- 国际申请: PCT/JP2009/071089 WO 20091218
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C12N5/071 ; G01N33/567
摘要:
The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods.The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.
公开/授权文献
- US08877449B2 Method for obtaining pancreatic progenitor cell using NEPH3 公开/授权日:2014-11-04
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