发明申请
- 专利标题： Humanized FcgR Mice
- 专利标题（中）： 人源化FcgR小鼠
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申请号： US13113677申请日： 2011-05-23
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公开(公告)号： US20110256556A1公开(公告)日： 2011-10-20
- 发明人: Lynn Macdonald , Naxin Tu , Cagan Gurer , Li-Hsien Wang , Sean Stevens , Andrew J. Murphy
- 申请人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Li-Hsien Wang , Sean Stevens , Andrew J. Murphy
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; G01N33/567 ; C12N5/00
摘要：
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
公开/授权文献
- US08883496B2 Humanized FcgR mice 公开/授权日：2014-11-11
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