发明申请
- 专利标题： HIGH AFFINITY NY-ESO T CELL RECEPTORS
- 专利标题（中）： 高亲属性NY-ESO T细胞受体
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申请号： US13176090申请日： 2011-07-05
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公开(公告)号： US20110262414A1公开(公告)日： 2011-10-27
- 发明人: Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
- 申请人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
- 申请人地址： GB Oxfordshire
- 专利权人： IMMUNOCORE LIMITED
- 当前专利权人： IMMUNOCORE LIMITED
- 当前专利权人地址： GB Oxfordshire
- 优先权： GB0411123.3 20040519; GB0419643.2 20040903
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61P35/00 ; C12N5/0783
摘要：
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
公开/授权文献
- US08367804B2 High affinity NY-ESO T cell receptors 公开/授权日：2013-02-05
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