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公开(公告)号：US08008438B2
公开(公告)日：2011-08-30
申请号：US12854691
申请日：2010-08-11
申请人： Jonathan Michael Boulter , Lucy Boulter, legal representative , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC (SEQ ID NO:126)-HLA-A*0201, the SLLMWITQC (SEQ ID NO:126) peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
摘要翻译： 本发明提供具有与SLLMWITQC（SEQ ID NO：126）-HLA-A * 0201结合的性质的T细胞受体（TCR），SLLMWITQC（SEQ ID NO：126）肽衍生自NY-ESO-1 由一系列肿瘤细胞表达的蛋白质。 所述TCR具有小于或等于1μM的肽-HLAI复合物的KD和/或具有1×10 -3 S -1或更低的脱离率（k off）的KD。
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公开(公告)号：US20110014169A1
公开(公告)日：2011-01-20
申请号：US12854691
申请日：2010-08-11
申请人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
IPC分类号： A61K35/12 , C07K14/725 , C12N5/07 , A61P35/00
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
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公开(公告)号：US08143376B2
公开(公告)日：2012-03-27
申请号：US11596458
申请日：2005-05-18
申请人： Jonathan Michael Boulter , Lucy Boulter, legal representative , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC (SEQ ID NO:126) peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
摘要翻译： 本发明提供具有与SLLMWITQC-HLA-A * 0201结合的性质的T细胞受体（TCR），SLLMWITQC（SEQ ID NO：126）肽衍生自NY-ESO-1蛋白质，其范围 的肿瘤细胞。 所述TCR具有小于或等于1μM的所述肽 - HLA复合物的KD和/或具有1×10 -3 S -1或更慢的脱离率（k off）。
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公开(公告)号：US20110262414A1
公开(公告)日：2011-10-27
申请号：US13176090
申请日：2011-07-05
申请人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
IPC分类号： A61K35/12 , A61P35/00 , C12N5/0783
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
摘要翻译： 本发明提供具有与SLLMWITQC-HLA-A * 0201结合的性质的T细胞受体（TCR），所述SLLMWITQC肽衍生自由一系列肿瘤细胞表达的NY-ESO-1蛋白。 所述TCR具有小于或等于1μM的肽-HLAI复合物的KD和/或具有1×10 -3 S -1或更低的脱离率（k off）的KD。
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公开(公告)号：US20110038842A1
公开(公告)日：2011-02-17
申请号：US11596458
申请日：2005-05-18
申请人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
摘要翻译： 本发明提供具有与SLLMWITQC-HLA-A * 0201结合的性质的T细胞受体（TCR），所述SLLMWITQC肽衍生自由一系列肿瘤细胞表达的NY-ESO-1蛋白。 所述TCR具有小于或等于1μM的肽-HLAI复合物的KD和/或具有1×10 -3 S -1或更低的脱离率（k off）的KD。
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公开(公告)号：US09156903B2
公开(公告)日：2015-10-13
申请号：US13429944
申请日：2012-03-26
申请人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C07K14/725 , C07K14/705 , A61K35/12 , A61K38/00
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
摘要翻译： 本发明提供具有与SLLMWITQC-HLA-A * 0201结合的性质的T细胞受体（TCR），来自NY-ESO-1蛋白的SLLMWITQC SEQ ID NO：126肽，其由一系列肿瘤 细胞。 所述TCR具有小于或等于1μM的所述肽 - HLA复合物的KD和/或具有1×10 -3 S -1或更慢的脱离率（k off）。
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公开(公告)号：US08367804B2
公开(公告)日：2013-02-05
申请号：US13176090
申请日：2011-07-05
发明人： Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
CPC分类号： C07K14/7051 , A61K35/12 , A61K38/00 , A61K39/39 , A61K2039/5156 , A61K2039/585 , C07K14/55 , C07K14/705 , C07K19/00 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
摘要翻译： 本发明提供具有与SLLMWITQC-HLA-A * 0201结合的性质的T细胞受体（TCR），来自NY-ESO-1蛋白的SLLMWITQC SEQ ID NO：126肽，其由一系列肿瘤 细胞。 所述TCR具有小于或等于1μM的所述肽 - HLA复合物的KD和/或具有1×10 -3 S -1或更慢的脱离率（k off）。
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公开(公告)号：US20100113300A1
公开(公告)日：2010-05-06
申请号：US12603255
申请日：2009-10-21
申请人： Bent Karsten Jakobsen , Torben Bent Andersen , Peter Eamon Molloy , Yi Li , Jonathan Michael Boulter
发明人： Bent Karsten Jakobsen , Torben Bent Andersen , Peter Eamon Molloy , Yi Li , Jonathan Michael Boulter
CPC分类号： C12N15/1037 , A61K38/00 , C07K14/7051 , C12N7/00 , C12N15/1041 , C12N15/1058 , C12N2795/18121 , C12N2795/18143 , C40B40/02 , C40B40/10
摘要： A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
摘要翻译： 蛋白质颗粒，例如噬菌体，核糖体或细胞，在其表面上显示T细胞受体（TCR）。 显示的TCR优选是在恒定结构域残基之间具有非天然二硫键的异源二聚体。 这种显示颗粒可用于创建用于鉴定高亲和性TCR的多种TCR文库。 披露了几个高亲和力。
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公开(公告)号：US08741814B2
公开(公告)日：2014-06-03
申请号：US12603255
申请日：2009-10-21
申请人： Bent Karsten Jakobsen , Torben Bent Andersen , Peter Eamon Molloy , Yi Li , Jonathan Michael Boulter
发明人： Bent Karsten Jakobsen , Torben Bent Andersen , Peter Eamon Molloy , Yi Li , Jonathan Michael Boulter
CPC分类号： C12N15/1037 , A61K38/00 , C07K14/7051 , C12N7/00 , C12N15/1041 , C12N15/1058 , C12N2795/18121 , C12N2795/18143 , C40B40/02 , C40B40/10
摘要： A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
摘要翻译： 蛋白质颗粒，例如噬菌体，核糖体或细胞，在其表面上显示T细胞受体（TCR）。 显示的TCR优选是在恒定结构域残基之间具有非天然二硫键的异源二聚体。 这种显示颗粒可用于创建用于鉴定高亲和性TCR的多种TCR文库。 披露了几个高亲和力。
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公开(公告)号：US20090214551A1
公开(公告)日：2009-08-27
申请号：US11887536
申请日：2006-03-29
CPC分类号： C07K14/705 , A61K38/00 , A61K47/6425 , C07K14/7051
摘要： The present invention provides TCRs having an affinity (KD) of less than or equal to 1 μM, and/or an off-rate (koff) of 1×10−3S−1 or slower, for the SLYNTVATL-HLA-A*0201 complex provided that when the said TCR is presented by cell and comprises SEQ ID NOS:1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.
摘要翻译： 对于所提供的SLYNTVATL-HLA-A * 0201复合物，本发明提供具有小于或等于1μM的亲和力（KD）和/或1×10 -3 S -1或更低的脱离率（k off）的TCR 当所述TCR由细胞呈递并且包含SEQ ID NO：1和2时，所述细胞不是天然T细胞。 这样的TCR单独或与治疗剂相关联，用于靶向呈现该复合物的HIV感染细胞。
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