发明申请
- 专利标题： DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS
- 专利标题（中）： 双作用吡唑抗菌剂
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申请号： US12984070申请日： 2011-01-04
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公开(公告)号： US20110275634A1公开(公告)日： 2011-11-10
- 发明人: Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- 申请人： Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE, INC.
- 当前专利权人： THERAVANCE, INC.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K31/4439 ; A61P13/12 ; A61K31/497 ; A61K31/506 ; A61K31/5377 ; A61K31/4155 ; A61K31/4245
摘要：
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US08119634B2 Dual-acting pyrazole antihypertensive agents 公开/授权日：2012-02-21
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