发明申请
- 专利标题： Compositions and Methods for Detection of Chromosomal Aberrations with Novel Hybridization Buffers
- 专利标题（中）： 用新型杂交缓冲液检测染色体畸变的组合物和方法
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申请号： US12994495申请日： 2009-05-27
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公开(公告)号： US20110281263A1公开(公告)日： 2011-11-17
- 发明人: Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen
- 申请人： Steen Hauge Matthiesen , Kenneth H. Petersen , Tim Svenstrup Poulsen
- 优先权： DKPA200800727 20080527; DKPA200900278 20090227
- 国际申请： PCT/IB09/06548 WO 20090527
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/82 ; G01N21/75 ; G01N21/64 ; G01N33/53 ; G01N33/574
摘要：
The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
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