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公开(公告)号：US11118214B2
公开(公告)日：2021-09-14
申请号：US12994492
申请日：2009-05-27
IPC分类号： G01N33/50 , C12Q1/6832 , C12Q1/6841 , C07H1/00
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
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公开(公告)号：US20110229975A1
公开(公告)日：2011-09-22
申请号：US12994492
申请日：2009-05-27
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q2527/125
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译： 本发明提供了用于将至少一种分子与目标物杂交的方法和组合物。 例如，本发明可以消除在杂交中使用或减少甲酰胺的依赖性。 用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使双链核苷酸序列变性。
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3.发明申请Compositions and Methods for Detection of Chromosomal Aberrations with Novel Hybridization Buffers 有权用新型杂交缓冲液检测染色体畸变的组合物和方法公开(公告)号：US20110281263A1
公开(公告)日：2011-11-17
申请号：US12994495
申请日：2009-05-27
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q2527/125
摘要： The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译： 本发明提供了用于检测与染色体畸变相关的核酸序列的组合物和方法。 例如，本发明可以消除在杂交中使用或减少甲酰胺的依赖性。 用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使双链核苷酸序列变性。
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4.发明授权Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers 有权用新型杂交缓冲液检测染色体畸变的组合物和方法公开(公告)号：US09297035B2
公开(公告)日：2016-03-29
申请号：US12994495
申请日：2009-05-27
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q2527/125
摘要： The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译： 本发明提供了用于检测与染色体畸变相关的核酸序列的组合物和方法。 例如，本发明可以消除在杂交中使用或减少甲酰胺的依赖性。 用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使双链核苷酸序列变性。
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公开(公告)号：US08877144B2
公开(公告)日：2014-11-04
申请号：US12747023
申请日：2008-12-09
CPC分类号： G01N1/2813 , G01N1/30 , G01N1/312
摘要： An apparatus for processing a biological sample is provided, the biological sample being arranged on a first planar surface of a carrier. The apparatus comprises a second planar surface arranged substantially parallel to said first planar surface and at a first distance from said first planar surface, said first planar surface and said second planar surface being arranged at an angle (A) greater than zero degree from the horizontal plane (HP); and supply means for supplying an amount of a liquid that is to be applied to said biological sample. The first planar surface and said second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.
摘要翻译： 提供了一种用于处理生物样品的装置，所述生物样品被布置在载体的第一平面表面上。 该装置包括基本上平行于所述第一平坦表面布置的第二平坦表面，并且距离所述第一平坦表面第一距离处，所述第一平面表面和所述第二平坦表面布置成与水平面成大于零度的角度（A） 飞机（HP）; 以及用于供给一定量的待施加到所述生物样品上的液体的供给装置。 所述第一平面和所述第二平面被配置为彼此间隔开第二距离，所述第二距离使得当所述第一平面和所述第二平面是所述第一平面和所述第二平面时，所述供应量的液体分布在所述生物样品上 带到彼此的第二距离。
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6.发明授权Apparatus and methods for processing biological samples and a reservoir therefor 有权用于处理生物样品的装置和方法及其储存器公开(公告)号：US07901634B2
公开(公告)日：2011-03-08
申请号：US11031514
申请日：2005-01-07
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes at least one reservoir (18) able to accommodate a fluid arranged on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译： 用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括至少一个储存器（18），其能够容纳布置在室内的表面上的流体，邻近和/ 至少一种生物样品的一部分。 该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。 充满水的储存器为室提供湿气并阻止样品干燥。
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7.发明授权Apparatus and methods for processing biological samples and a reservoir therefor 有权用于处理生物样品的装置和方法及其储存器公开(公告)号：US08632739B2
公开(公告)日：2014-01-21
申请号：US13472777
申请日：2012-05-16
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
IPC分类号： B01L3/00
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译： 用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括：至少一个储存器（18），其能够容纳与所述腔室内的表面相邻和/或面对实质的流体 至少一种生物样品的一部分。 该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。 充满水的储存器为室提供湿气并阻止样品干燥。
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8.发明授权Apparatus and methods for processing biological samples and a reservoir therefor 有权用于处理生物样品的装置和方法及其储存器公开(公告)号：US08211385B2
公开(公告)日：2012-07-03
申请号：US13016374
申请日：2011-01-28
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译： 用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括：至少一个储存器（18），其能够容纳与所述腔室内的表面相邻和/或面对实质的流体 至少一种生物样品的一部分。 该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。 充满水的储存器为室提供湿气并阻止样品干燥。
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9.发明申请APPARATUS AND METHODS FOR PROCESSING BIOLOGICAL SAMPLES AND A RESERVOIR THEREFOR 有权用于处理生物样品和储存器的装置和方法公开(公告)号：US20110189782A1
公开(公告)日：2011-08-04
申请号：US13016374
申请日：2011-01-28
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译： 用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括：至少一个储存器（18），其能够容纳与所述腔室内的表面相邻和/或面对实质的流体 至少一种生物样品的一部分。 该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。 充满水的储存器为室提供湿气并阻止样品干燥。
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10.发明申请Apparatus and Methods For Processing Biological Samples and a Reservoir Therefor 有权用于处理生物样品及其储存器的装置和方法公开(公告)号：US20130023038A1
公开(公告)日：2013-01-24
申请号：US13472777
申请日：2012-05-16
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
IPC分类号： C12M1/34
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译： 用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括：至少一个储存器（18），其能够容纳与所述腔室内的表面相邻和/或面对实质的流体 至少一种生物样品的一部分。 该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。 充满水的储存器为室提供湿气并阻止样品干燥。
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