发明申请
- 专利标题: DISSOLUTION STABILITY OF CALCIUM CARBONATE TABLETS
- 专利标题(中): 碳酸钙片的溶解稳定性
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申请号: US13129664申请日: 2009-11-17
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公开(公告)号: US20110287098A1公开(公告)日: 2011-11-24
- 发明人: Peder Mohr Olsen , Poul Egon Bertelsen , Thomas Thisted , Henrik Ravn Aage
- 申请人: Peder Mohr Olsen , Poul Egon Bertelsen , Thomas Thisted , Henrik Ravn Aage
- 申请人地址: NO Asker
- 专利权人: NYCOMED PHARMA AS
- 当前专利权人: NYCOMED PHARMA AS
- 当前专利权人地址: NO Asker
- 优先权: EP08169264.2 20081117
- 国际申请: PCT/EP2009/008157 WO 20091117
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K9/42 ; A61K33/10
摘要:
The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
公开/授权文献
- US09101565B2 Dissolution stability of calcium carbonate tablets 公开/授权日:2015-08-11
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