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39 条记录 (耗时 0.042 秒)

    Dissolution stability of calcium carbonate tablets
    1.
    发明授权
    Dissolution stability of calcium carbonate tablets 有权
    碳酸钙片的溶解稳定性

    公开(公告)号：US09101565B2

    公开(公告)日：2015-08-11

    申请号：US13129664

    申请日：2009-11-17

    申请人： Peder Mohr Olsen ,  Poul Egon Bertelsen ,  Thomas Thisted ,  Henrik Ravn Aage

    发明人： Peder Mohr Olsen ,  Poul Egon Bertelsen ,  Thomas Thisted ,  Henrik Ravn Aage

    IPC分类号： A61K33/10 ,  A61K47/26 ,  A61K33/06 ,  A61K9/20

    CPC分类号： A61K33/10 ,  A61J3/10 ,  A61K9/2018 ,  A61K9/2072 ,  A61K9/2095 ,  A61K9/282 ,  A61K33/06

    摘要： The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.

    摘要翻译： 本发明涉及一种制备包含至少50％w / w碳酸钙的片剂的方法，所述方法包括i）提供包含a）碳酸钙的颗粒组合物，b）选自山梨醇或 异麦芽酮糖醇或其组合，c）选自甘露醇，麦芽糖醇或木糖醇的非结合性糖醇或其组合，以及ii）使用配备有至少一对冲头和模具的压片机压缩所述组合物，其中所述对 用含有选自硬脂酸镁，硬脂酸钙或硬脂酸的润滑剂或其组合的润滑剂的组合物喷涂用所述颗粒组合物填充模头之前的冲头和模具。

    METHOD FOR PRODUCING SECOND-GENERATION LIBRARY
    6.
    发明申请
    METHOD FOR PRODUCING SECOND-GENERATION LIBRARY 有权
    生产第二代图书馆的方法

    公开(公告)号：US20120028812A1

    公开(公告)日：2012-02-02

    申请号：US13179283

    申请日：2011-07-08

    申请人： Per-Ola FRESKGARD ,  Alex Haahr GOULIAEV ,  Thomas THISTED ,  Eva Kampmann OLSEN

    发明人： Per-Ola FRESKGARD ,  Alex Haahr GOULIAEV ,  Thomas THISTED ,  Eva Kampmann OLSEN

    IPC分类号： C40B10/00

    CPC分类号： C40B40/08 ,  B01J19/0046 ,  B01J2219/00592 ,  C12N15/1068 ,  C12Q1/6811 ,  C40B50/04 ,  C40B50/06 ,  C40B50/10 ,  C12Q2565/501 ,  C12Q2531/113

    摘要： The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons identifying chemical entities that have participated in the formation of the encoded molecule is provided. In a second step, the library is partitioned and encoded molecules having a certain property are selected. Codons of identifiers of selected encoded molecules are subsequently identified, and a second-generation library is prepared using at least some of the chemical entities coded for by the identified codons. The new focussed library may be used for another partition step to select encoded molecules with a certain property.

    摘要翻译： 本发明涉及生成第二代文库的方法。 在第一步中，提供了与标识符核酸相关联的编码分子的文库，其包含鉴定参与编码分子形成的化学实体的密码子。 在第二步中，分离文库，并选择具有一定性质的编码分子。 随后鉴定所选编码分子的标识符的密码子，并且使用由鉴定的密码子编码的至少一些化学实体来制备第二代文库。 新的聚焦库可以用于另一个分割步骤以选择具有一定特性的编码分子。

    Method for Obtaining Structural Information Concerning an Encoded Molecule and Method for Selecting Compounds
    9.
    发明申请
    Method for Obtaining Structural Information Concerning an Encoded Molecule and Method for Selecting Compounds 审中-公开
    获得编码分子结构信息的方法和选择化合物的方法

    公开(公告)号：US20080305957A1

    公开(公告)日：2008-12-11

    申请号：US10572644

    申请日：2004-09-17

    申请人： Thomas Thisted ,  Mikkel Dybro Lundorf ,  Per-Ola Freskgard ,  Torben Ravn Rasmussen

    发明人： Thomas Thisted ,  Mikkel Dybro Lundorf ,  Per-Ola Freskgard ,  Torben Ravn Rasmussen

    IPC分类号： C40B20/04

    CPC分类号： C12Q1/6837 ,  C12N15/1068 ,  C12Q1/6811 ,  C12Q2531/113 ,  C12Q2565/501

    摘要： In one aspect, the present invention relates to a method for obtaining structural information about an encoded molecule. The encoded molecule may be produced by a reaction of a plurality of chemical entities and may be capable of being connected to an identifier oligonucleotide containing codons informative of the identity of the chemical entities which have participated in the formation of the encoded molecule. In a certain embodiment, primers are designed complementary to the codons appearing on the identifier oligonucleotide, and the presence, absence or relative abundance of a codon is evaluated by mixing a primer with the identifier oligonucleotide in the presence of a polymerase and substrate (deoxy)ribonucleotide triphosphates and measuring the extension reaction. In another aspect, the invention provides a method for selecting compounds which binds to a target. More specifically, the invention relates to a method in which a target associated with an oligonucleotide initially is mixed with a library of complexes, each complex comprising a display molecule and an oligonucleotide identifying said display molecule. Next, due an increased proximity, the target oligonucleotide is coupled to the identifier oligonucleotide of complexes having a display molecule with affinity towards the target. In a final stage the coupled nucleotides are analysed to deduce at least the identity of the display molecule.

    摘要翻译： 一方面，本发明涉及获得关于编码分子的结构信息的方法。 编码的分子可以通过多个化学实体的反应产生，并且可以能够连接到含有密码子的标识符寡核苷酸，该密码子包括参与编码分子形成的化学实体的身份。 在一些实施方案中，设计引物与出现在标识寡核苷酸上的密码子互补，并且通过在聚合酶和底物（脱氧））存在下将引物与标识寡核苷酸混合来评估密码子的存在，不存在或相对丰度， 核糖核苷三磷酸并测量延伸反应。 另一方面，本发明提供了选择与靶标结合的化合物的方法。 更具体地，本发明涉及一种方法，其中与寡核苷酸相关的靶标最初与复合物文库混合，每个复合物包含显示分子和识别所述显示分子的寡核苷酸。 接下来，由于接近度增加，靶寡核苷酸与具有与靶具有亲和性的显示分子的复合物的标识符寡核苷酸偶联。 在最后阶段，分析耦合的核苷酸以至少推断显示分子的身份。

    Method for producing second-generation library
    10.
    发明申请
    Method for producing second-generation library 审中-公开
    第二代图书馆制作方法

    公开(公告)号：US20070026397A1

    公开(公告)日：2007-02-01

    申请号：US10546538

    申请日：2004-02-23

    申请人： Per-Ola Freskgard ,  Alex Gouliaev ,  Thomas Thisted ,  Eva Olsen

    发明人： Per-Ola Freskgard ,  Alex Gouliaev ,  Thomas Thisted ,  Eva Olsen

    IPC分类号： C40B30/06 ,  C40B40/08

    CPC分类号： C40B40/08 ,  B01J19/0046 ,  B01J2219/00592 ,  C12N15/1068 ,  C12Q1/6811 ,  C40B50/04 ,  C40B50/06 ,  C40B50/10 ,  C12Q2565/501 ,  C12Q2531/113

    摘要： The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons identifying chemical entities that have participated in the formation of the encoded molecule is provided. In a second step, the library is partitioned and encoded molecules having a certain property are selected. Codons of identifiers of selected encoded molecules are subsequently identified, and a second-generation library is prepared using at least some of the chemical entities coded for by the identified codons. The new focused library may be used of another partition step to select encoded molecules with a certain property.

    摘要翻译： 本发明涉及生成第二代文库的方法。 在第一步中，提供了与标识符核酸相关联的编码分子的文库，其包含鉴定参与编码分子形成的化学实体的密码子。 在第二步中，分离文库，并选择具有一定性质的编码分子。 随后鉴定所选编码分子的标识符的密码子，并且使用由鉴定的密码子编码的至少一些化学实体来制备第二代文库。 新的聚焦库可以用于另一个分割步骤来选择具有某种特性的编码分子。