公开(公告)号：US09101565B2

公开(公告)日：2015-08-11

申请号：US13129664

申请日：2009-11-17

申请人： Peder Mohr Olsen ,  Poul Egon Bertelsen ,  Thomas Thisted ,  Henrik Ravn Aage

发明人： Peder Mohr Olsen ,  Poul Egon Bertelsen ,  Thomas Thisted ,  Henrik Ravn Aage

IPC分类号： A61K33/10 ,  A61K47/26 ,  A61K33/06 ,  A61K9/20

CPC分类号： A61K33/10 ,  A61J3/10 ,  A61K9/2018 ,  A61K9/2072 ,  A61K9/2095 ,  A61K9/282 ,  A61K33/06

摘要： The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.

摘要翻译： 本发明涉及一种制备包含至少50％w / w碳酸钙的片剂的方法，所述方法包括i）提供包含a）碳酸钙的颗粒组合物，b）选自山梨醇或 异麦芽酮糖醇或其组合，c）选自甘露醇，麦芽糖醇或木糖醇的非结合性糖醇或其组合，以及ii）使用配备有至少一对冲头和模具的压片机压缩所述组合物，其中所述对 用含有选自硬脂酸镁，硬脂酸钙或硬脂酸的润滑剂或其组合的润滑剂的组合物喷涂用所述颗粒组合物填充模头之前的冲头和模具。

公开(公告)号：US20110287098A1

公开(公告)日：2011-11-24

申请号：US13129664

申请日：2009-11-17

申请人： Peder Mohr Olsen ,  Poul Egon Bertelsen ,  Thomas Thisted ,  Henrik Ravn Aage

发明人： Peder Mohr Olsen ,  Poul Egon Bertelsen ,  Thomas Thisted ,  Henrik Ravn Aage

IPC分类号： A61K9/20 ,  A61K9/42 ,  A61K33/10

CPC分类号： A61K33/10 ,  A61J3/10 ,  A61K9/2018 ,  A61K9/2072 ,  A61K9/2095 ,  A61K9/282 ,  A61K33/06

摘要： The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.

摘要翻译： 本发明涉及一种制备包含至少50％w / w碳酸钙的片剂的方法，所述方法包括i）提供包含a）碳酸钙的颗粒组合物，b）选自山梨醇或 异麦芽酮糖醇或其组合，c）选自甘露醇，麦芽糖醇或木糖醇的非结合性糖醇或其组合，以及ii）使用配备有至少一对冲头和模具的压片机压缩所述组合物，其中所述对 用含有选自硬脂酸镁，硬脂酸钙或硬脂酸的润滑剂或其组合的润滑剂的组合物喷涂用所述颗粒组合物填充模头之前的冲头和模具。