发明申请
- 专利标题： Inhibitors of AKT Activity
- 专利标题（中）： AKT活性抑制剂
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申请号： US13147392申请日： 2010-01-25
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公开(公告)号： US20110288090A1公开(公告)日： 2011-11-24
- 发明人: Donna J. Armstrong , Yasuhiro Goto , Takashi Hashihayata , Tetsuya Kato , Michael J. Kelly, III , Mark E. Layton , Craig W. Lindsley , Yoshio Ogino , Yu Onozaki , Kenvin J. Rodzinak , Michael A. Rossi , Philip E. Sanderson , Jiabing Wang , Melissa M. Yaroschak
- 申请人： Donna J. Armstrong , Yasuhiro Goto , Takashi Hashihayata , Tetsuya Kato , Michael J. Kelly, III , Mark E. Layton , Craig W. Lindsley , Yoshio Ogino , Yu Onozaki , Kenvin J. Rodzinak , Michael A. Rossi , Philip E. Sanderson , Jiabing Wang , Melissa M. Yaroschak
- 国际申请： PCT/US2010/021945 WO 20100125
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/4985 ; A61K31/496 ; A61K31/506 ; A61K31/498 ; A61K31/438 ; A61K31/4375 ; C07D475/04 ; C07D471/04 ; C07D401/12 ; A61P35/00 ; A61K31/519
摘要：
The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
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