发明申请
US20110293522A1 SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS
审中-公开
通过表面活性和反应性末端组合聚合物的表面改性
- 专利标题: SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS
- 专利标题(中): 通过表面活性和反应性末端组合聚合物的表面改性
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申请号: US13129438申请日: 2009-11-16
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公开(公告)号: US20110293522A1公开(公告)日: 2011-12-01
- 发明人: Shanger Wang , Robert S. Ward , Yuan Tian , Xuwei Jiang , Keith Mccrea , Scott Curtin
- 申请人: Shanger Wang , Robert S. Ward , Yuan Tian , Xuwei Jiang , Keith Mccrea , Scott Curtin
- 申请人地址: NL Heerlen
- 专利权人: DSM IP ASSETS B.V.
- 当前专利权人: DSM IP ASSETS B.V.
- 当前专利权人地址: NL Heerlen
- 国际申请: PCT/US09/64560 WO 20091116
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; B29C45/00 ; A61P31/00 ; A61P7/02 ; C08G18/83 ; A61K31/785
摘要:
Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.