利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.014 秒)

    Low-Tack, Hydrophobic Ophthalmic Device Materials
    2.
    发明申请
    Low-Tack, Hydrophobic Ophthalmic Device Materials 有权
    低粘度，疏水性眼科装置材料

    公开(公告)号：US20120202916A1

    公开(公告)日：2012-08-09

    申请号：US13367914

    申请日：2012-02-07

    申请人： Walter R. Laredo ,  Xuwei Jiang

    发明人： Walter R. Laredo ,  Xuwei Jiang

    IPC分类号： G02C7/04 ,  C08L83/12

    CPC分类号： G02B1/043 ,  C08L83/04 ,  C08L51/085 ,  C08L33/08

    摘要： Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing block copolymer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.

    摘要翻译： 公开了低粘度，疏水性，高折射率，丙烯酸材料。 这些特别用作眼内透镜材料的材料含有一种或多种芳基丙烯酸疏水性单体作为主要的成形单体，降粘嵌段共聚物添加剂和减轻闪光的添加剂。 除了它们用作眼内透镜材料之外，本材料还适用于其它可植入眼科装置。

    Low-tack, hydrophobic ophthalmic device materials
    3.
    发明授权
    Low-tack, hydrophobic ophthalmic device materials 有权
    低粘度，疏水性眼科装置材料

    公开(公告)号：US08969429B2

    公开(公告)日：2015-03-03

    申请号：US13367914

    申请日：2012-02-07

    申请人： Walter R. Laredo ,  Xuwei Jiang

    发明人： Walter R. Laredo ,  Xuwei Jiang

    IPC分类号： C08L33/08 ,  G02B1/04

    CPC分类号： G02B1/043 ,  C08L83/04 ,  C08L51/085 ,  C08L33/08

    摘要： Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing block copolymer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.

    摘要翻译： 公开了低粘度，疏水性，高折射率，丙烯酸材料。 这些特别用作眼内透镜材料的材料含有一种或多种芳基丙烯酸疏水性单体作为主要的成形单体，降粘嵌段共聚物添加剂和减轻闪光的添加剂。 除了它们用作眼内透镜材料之外，本材料还适用于其它可植入眼科装置。

    Functionalization of polyglycolides by “click” chemistry
    4.
    发明授权
    Functionalization of polyglycolides by “click” chemistry 有权
    通过“点击”化学功能化聚乙交酯

    公开(公告)号：US08927682B2

    公开(公告)日：2015-01-06

    申请号：US12229544

    申请日：2008-08-25

    申请人： Gregory L. Baker ,  Milton R. Smith, III ,  Xuwei Jiang ,  Erin B. Vogel

    发明人： Gregory L. Baker ,  Milton R. Smith, III ,  Xuwei Jiang ,  Erin B. Vogel

    IPC分类号： C08G63/08 ,  C08G63/82

    CPC分类号： C08G63/08 ,  C08G63/823

    摘要： Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.

    摘要翻译： 公开了聚（乙交酯）聚合物。 聚合物通常包括聚合的炔基取代的乙交酯，其具有带有一个或多个炔基的聚合物主链。 炔基提供用于聚合物进一步官能化的反应位点，例如通过与叠氮化物衍生物（例如叠氮取代的有机化合物）反应。 炔基和叠氮基通过“点击”化学机理反应以形成通过三唑连接共价键合到聚合物上的官能团。 聚合物是可生物降解的，并且可以用于在患者身体的目标位置和/或以控制释放速率递送药物或其它治疗物质（例如大的生物分子，例如单链RNA）。

    SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS
    5.
    发明申请
    SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS 审中-公开
    含硅胶的单体含有疏水末端基团

    公开(公告)号：US20140135408A1

    公开(公告)日：2014-05-15

    申请号：US13982713

    申请日：2012-02-01

    申请人： Shanger Wang ,  Xuwei Jiang ,  Yuan Tian

    发明人： Shanger Wang ,  Xuwei Jiang ,  Yuan Tian

    IPC分类号： G02B1/04

    CPC分类号： G02B1/043 ,  C07F7/0838 ,  C07F7/1804 ,  C07F9/091 ,  C07F9/092 ,  C07F9/65742 ,  C08G77/045 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08K5/5425 ,  C08L101/14 ,  C08L83/04 ,  C08F2230/085 ,  C08F220/20 ,  C08F220/54 ,  C08F2220/286

    摘要： Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R1 is H or CH3, a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R51, R52, R53 are independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group attached, preferably to the terminal end of R51, R52, R53, X is O or NR54, where R54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R2 and R3 are independently an alkyl, alkyl ether, or a substituted or non-substituted aromatic group, preferred R2 and R3 include methyl, ethyl, and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, and substituted and unsubstituted heterocyclic groups. Suitable substituents include aryl, amine, ether, amide, hydroxyl groups, combinations thereof and the like. In another embodiment, L comprises a straight or branched alkylene group having 2 to 12 carbons. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-bio-logic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices.

    摘要翻译： 公开了含有亲水性末端基团的含有有机硅的反应性单体，其可用于制造生物相容性医疗器械，其中R1为H或CH3，a为0或1，p为1至6的整数，q为 1至3，对于q，端基R 51，R 52，R 53独立地为烷基，烷基醚，三甲基甲硅烷氧基或取代或未取代的芳族基团，并且其中至少一个具有连接的亲水基团，优选至 R51，R52，R53，X的末端是O或NR54，其中R54是H或具有1至4个碳的一价烷基，n是1到100的整数，R2和R3独立地是烷基，烷基醚 ，或取代或未取代的芳族基团，优选的R 2和R 3包括甲基，乙基和苯基，L是包含具有1-14个碳原子的取代和未取代的亚烷基的二价连接基，其可以是直链或支链的，取代的和 具有2-12个碳原子的未取代的烷氧基，聚醚 ，恶唑啉，以及取代和未取代的杂环基。 合适的取代基包括芳基，胺，醚，酰胺，羟基，它们的组合等。 在另一个实施方案中，L包含具有2至12个碳的直链或支链亚烷基。 反应性单体将透氧硅氧烷组分与能够达到器件 - 生物逻辑界面的亲水端基组合，从而提供用于制造医疗装置，特别是眼用装置的体积和表面特性。

    "> Functionalization of polyglycolides by
    6.
    发明申请
    Functionalization of polyglycolides by "click" chemistry 有权
    通过“点击”化学功能化聚乙交酯

    公开(公告)号：US20090054619A1

    公开(公告)日：2009-02-26

    申请号：US12229544

    申请日：2008-08-25

    申请人： Gregory L. Baker ,  Milton R. Smith, III ,  Xuwei Jiang ,  Erin B. Vogel

    发明人： Gregory L. Baker ,  Milton R. Smith, III ,  Xuwei Jiang ,  Erin B. Vogel

    IPC分类号： C08G63/08

    CPC分类号： C08G63/08 ,  C08G63/823

    摘要： Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.

    摘要翻译： 公开了聚（乙交酯）聚合物。 聚合物通常包括聚合的炔基取代的乙交酯，其具有带有一个或多个炔基的聚合物主链。 炔基提供用于聚合物进一步官能化的反应位点，例如通过与叠氮化物衍生物（例如叠氮取代的有机化合物）反应。 炔基和叠氮基通过“点击”化学机理反应以形成通过三唑连接共价键合到聚合物上的官能团。 聚合物是可生物降解的，并且可以用于在患者身体的目标位置和/或以控制释放速率递送药物或其它治疗物质（例如大的生物分子，例如单链RNA）。

    SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS
    9.
    发明申请
    SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS 审中-公开
    通过表面活性和反应性末端组合聚合物的表面改性

    公开(公告)号：US20110293522A1

    公开(公告)日：2011-12-01

    申请号：US13129438

    申请日：2009-11-16

    申请人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

    发明人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

    IPC分类号： A61K49/00 ,  B29C45/00 ,  A61P31/00 ,  A61P7/02 ,  C08G18/83 ,  A61K31/785

    CPC分类号： C08G18/837 ,  A61K2800/61 ,  C08G18/08 ,  C08J7/12 ,  C08J7/14

    摘要： Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.

    摘要翻译： 聚合物表面改性方法包括以下步骤：在制品制造期间首先形成与聚合物链末端连接的主要反应性端基的表面，然后用生物活性分子，亲水和疏水单体，低聚物或聚合物改性活性表面 以获得特定的表面性质。 或者，多功能偶联剂可用于将主反应性基团与能够与与生物活性分子，亲水和疏水单体，低聚物和聚合物相关的官能团反应的第二反应性基团，以获得特定的表面性质。 本发明涉及将表面活性隔离物连接到聚合物链末端的反应性端基引入表面。 表面活性间隔物允许反应性端基在制造过程中迁移和富集到表面。 本发明提供具有抗血栓形成性质，润滑性，选择性吸附和抗微生物性质的生物界面的医疗装置。