公开(公告)号：US20110293522A1

公开(公告)日：2011-12-01

申请号：US13129438

申请日：2009-11-16

申请人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

发明人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

IPC分类号： A61K49/00 ,  B29C45/00 ,  A61P31/00 ,  A61P7/02 ,  C08G18/83 ,  A61K31/785

CPC分类号： C08G18/837 ,  A61K2800/61 ,  C08G18/08 ,  C08J7/12 ,  C08J7/14

摘要： Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.

摘要翻译： 聚合物表面改性方法包括以下步骤：在制品制造期间首先形成与聚合物链末端连接的主要反应性端基的表面，然后用生物活性分子，亲水和疏水单体，低聚物或聚合物改性活性表面 以获得特定的表面性质。 或者，多功能偶联剂可用于将主反应性基团与能够与与生物活性分子，亲水和疏水单体，低聚物和聚合物相关的官能团反应的第二反应性基团，以获得特定的表面性质。 本发明涉及将表面活性隔离物连接到聚合物链末端的反应性端基引入表面。 表面活性间隔物允许反应性端基在制造过程中迁移和富集到表面。 本发明提供具有抗血栓形成性质，润滑性，选择性吸附和抗微生物性质的生物界面的医疗装置。