发明申请
US20110313166A1 MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
有权
（E）-N-4-（二甲基氨基）-2-丁酮及其结晶形式的色谱柱
- 专利标题： MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
- 专利标题（中）： （E）-N-4-（二甲基氨基）-2-丁酮及其结晶形式的色谱柱
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申请号： US13181375申请日： 2011-07-12
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公开(公告)号： US20110313166A1公开(公告)日： 2011-12-22
- 发明人: Qinghong LU , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
- 申请人： Qinghong LU , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
- 主分类号： C07D401/12
- IPC分类号： C07D401/12
摘要：
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
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