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![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/abs-image/US/2011/09/20/US08022216B2/abs.jpg.150x150.jpg)
1.发明授权Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof 有权（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式公开(公告)号：US08022216B2
公开(公告)日：2011-09-20
申请号：US12251924
申请日：2008-10-15
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D215/44
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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2.发明申请MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF 有权（E）-N-4-（二甲基氨基）-2-丁酮及其结晶形式的色谱柱公开(公告)号：US20090176827A1
公开(公告)日：2009-07-09
申请号：US12251924
申请日：2008-10-15
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： A61K31/4709 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-buteramide and crystalline forms thereof](/abs-image/US/2013/03/12/US08394959B2/abs.jpg.150x150.jpg)
3.发明授权Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-buteramide and crystalline forms thereof 有权（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基）-4-（二甲基氨基）-2-丁酰胺的马来酸盐和 其结晶形式公开(公告)号：US08394959B2
公开(公告)日：2013-03-12
申请号：US13441168
申请日：2012-04-06
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/abs-image/US/2012/05/08/US08173814B2/abs.jpg.150x150.jpg)
4.发明授权Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof 有权（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式公开(公告)号：US08173814B2
公开(公告)日：2012-05-08
申请号：US13181375
申请日：2011-07-12
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D215/44
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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5.发明申请MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF 有权（E）-N-4-（二甲基氨基）-2-丁酮及其结晶形式的色谱柱公开(公告)号：US20110313166A1
公开(公告)日：2011-12-22
申请号：US13181375
申请日：2011-07-12
申请人： Qinghong LU , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong LU , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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6.发明申请Maleate Salts of (E)-N--4-(Dimethylamino)-2-Butenamide and Crystalline Forms Thereof 有权（E）-N-4-（二甲基氨基）-2-丁烯酰胺的马来酸盐及其结晶形式公开(公告)号：US20120289545A1
公开(公告)日：2012-11-15
申请号：US13441168
申请日：2012-04-06
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： A61K31/4709 , C07D401/14 , A61P35/00 , C07D401/12
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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