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    Synthesis and characterization of polymorph form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-YL)thiazol-4-YL)benzonitrile
    7.
    发明申请
    Synthesis and characterization of polymorph form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-YL)thiazol-4-YL)benzonitrile 审中-公开
    4-（2-（4,4-二甲基-2-氧代恶唑烷-3-基）噻唑-4-基）苄腈的多晶型II的合成和表征

    公开(公告)号：US20080234340A1

    公开(公告)日：2008-09-25

    申请号：US12075228

    申请日：2008-03-10

    申请人： Mahmoud Mirmehrabi ,  Yuping Niu ,  Abdolsamad Tadayon ,  Subodh Deshmukh ,  Mannching Sherry Ku

    发明人： Mahmoud Mirmehrabi ,  Yuping Niu ,  Abdolsamad Tadayon ,  Subodh Deshmukh ,  Mannching Sherry Ku

    IPC分类号： A61K31/427 ,  C07D413/02 ,  A61P35/00 ,  A61P5/24

    CPC分类号： C07D417/04

    摘要： A polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile and methods of preparing Form II are described. Also provided are methods of contraception, treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake, and synchronizing estrus including using polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile.Further provided are methods for preparing polymorph Form I of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile from polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile.

    摘要翻译： 描述了4-（2-（4,4-二甲基-2-氧代恶唑烷-3-基）噻唑-4-基）苄腈的多晶型II和制备形式II的方法。 还提供了避孕，治疗或预防子宫肌瘤，子宫平滑肌瘤，子宫内膜异位症，功能障碍性出血，多囊卵巢综合征和激素依赖性癌症的方法，提供激素替代疗法，刺激食物摄入和同步发情，包括使用4- （2-（4,4-二甲基-2-氧代恶唑烷-3-基）噻唑-4-基）苄腈。 进一步提供的是由4-（2-（4,4-二甲基-2-氧代恶唑烷-3-基）噻唑-4-基）苄腈的多晶型II制备多晶型物I的方法， 4-二甲基-2-氧代恶唑烷-3-基）噻唑-4-基）苄腈。

    Polymorph form II of tanaproget
    10.
    发明授权
    Polymorph form II of tanaproget 失效
    tanaproget的多晶型II

    公开(公告)号：US08114869B2

    公开(公告)日：2012-02-14

    申请号：US13106494

    申请日：2011-05-12

    申请人： Marc Sadler Tesconi ,  Mannching Sherry Ku ,  Yan Xu

    发明人： Marc Sadler Tesconi ,  Mannching Sherry Ku ,  Yan Xu

    IPC分类号： A61K31/536 ,  A61P15/18 ,  C07D265/18

    CPC分类号： C07D413/04 ,  C07D265/18 ,  C07B2200/13

    摘要： Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.

    摘要翻译： Tanaproget多晶型物II，制备tanaproget多晶型II的方法，包括tanaproget多晶型II，微粉化tanaproget多晶型II的药物组合物，以及将II型转化成tanaproget形式I的方法。 还提供了避孕，激素替代疗法，刺激食物摄取和治疗或预防子宫肌层肌瘤，良性前列腺肥大，良性和恶性肿瘤性疾病，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症，多囊卵巢综合征或癌和腺癌的方法，包括 向哺乳动物受试者施用多晶型II。