发明申请
- 专利标题： INHIBITORS OF AKT ACTIVITY
- 专利标题（中）： AKT活动的抑制剂
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申请号： US13255785申请日： 2010-03-03
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公开(公告)号： US20120004240A1公开(公告)日： 2012-01-05
- 发明人: Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
- 申请人： Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
- 国际申请： PCT/US2010/026796 WO 20100303
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61P35/00 ; A61K31/4375 ; C07D401/14 ; A61K31/519
摘要：
The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
公开/授权文献
- US08614221B2 Inhibitors of Akt activity 公开/授权日：2013-12-24