摘要:
The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要:
The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要:
The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer.
摘要:
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity especially Akt1 by administering the compound to a patient in need of treatment of cancer.
摘要:
The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer.
摘要:
The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要:
An object of the present invention is to provide an apparatus for measuring biological signals, which is capable of displaying marker lines on a time axis in synchronism with a particular position of a reference wave so that, if an electrocardiogram is selected as the reference wave, a plurality of other biological signals can be monitored in comparison with the electrocardiogram. According to the present invention, an apparatus for measuring biological signals includes an input unit for simultaneously receiving and amplifying a plurality of biological signal waveforms; a memory device for storing the plurality of biological signal waveforms input through the input device; a marker line synchronizing position setting device for determining a marker position by setting an arbitrary position of at least a single biological signal waveform that serves as a reference signal selected from the plurality of biological signal waveforms stored in the memory device; a marker line generating device for generating a marker line at the position set by the marker line synchronizing position setting device; and a display device for displaying the plurality of biological signal waveforms stored in the memory device and displaying the marker line generated by the marker line generating device such that it intersects the time axis of the plurality of biological signal waveforms orthogonally.
摘要:
An induction heating cooking apparatus includes a pan supporting plate made of a flat sheet of a heat-resistant dielectric material, a heating coil for induction heating disposed below the pan supporting plate, and touch pads each constituting a capacitor-pair formed by first, second and third electrodes. The touch pads when including three pads respectively serves for turning on a power supply, for turning off the power supply, and for setting a power level to a predetermined level. The induction heating or the supply of the power is permitted to take place only when the touch pad is first touched and followed by touching the touch pad. The first electrodes of the touch pads are provided on the upper surface of the pan supporting plate, and are enclosed by guard rings of a conductive material to prevent erroneous operation.
摘要:
A frequency converter having a silicon controlled rectifier comprises a protection circuit which includes a series resonant circuit connected in parallel with the silicon controlled rectifier to generate a reverse voltage thereacross in response to a short circuit established in response to a commutation failure of the silicon controlled rectifier. An inhibit circuit is provided to respond to the reverse voltage by inhibiting the current flow through the silicon controlled rectifier to allow the same to restore to its locking state.