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公开(公告)号:US20120004240A1
公开(公告)日:2012-01-05
申请号:US13255785
申请日:2010-03-03
申请人: Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
发明人: Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
IPC分类号: A61K31/4985 , A61P35/00 , A61K31/4375 , C07D401/14 , A61K31/519
CPC分类号: C07D471/14 , C07D487/14 , C07D519/00
摘要: The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译: 本发明提供抑制Akt活性的取代的稠合萘啶衍生物。 特别地,所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号:US08614221B2
公开(公告)日:2013-12-24
申请号:US13255785
申请日:2010-03-10
申请人: Weiming Fan , Thomas F. N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
发明人: Weiming Fan , Thomas F. N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
IPC分类号: A61K31/519 , C07D471/12
CPC分类号: C07D471/14 , C07D487/14 , C07D519/00
摘要: The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译: 本发明提供抑制Akt活性的取代的稠合萘啶衍生物。 特别地,所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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